Rabbit Anti-APC2 Antibody (MO-DKB-02296W)
Cat: MO-DKB-02296W
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- Product Details
Specifications
| Host species | Rabbit (Oryctolagus cuniculus) |
| Species Reactivity | A. thaliana (Arabidopsis thaliana) |
| Immunogen | APC2 synthetic peptide derived from Arabidopsis AT2G04660. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | Peptide affinity purified |
Application Information
| Application | IP, IF |
| Application Notes | Immunoprecipitation; Immunofluorescence Note: Optimal dilutions/concentrations should be determined by the end user. |
Target
| Introduction | This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. This gene also plays a role in actin assembly, cell-cell adhesion, and microtubule network formation through its interaction with cytoskeletal proteins. This gene has its highest expression in the central nervous system and is involved in brain development through cytoskeletal regulation in neurons. Alternative splicing produces multiple transcript variants encoding distinct isoforms. |
| Product Overview | This product is a Rabbit antibody against the APC2. It can be used for APC2 detection in Immunoprecipitation; Immunofluorescence. |
| Alternative Names | APC2, WNT Signaling Pathway Regulator; Adenomatous Polyposis Coli Like; Adenomatosis Polyposis Coli 2; APCL; Adenomatous Polyposis Coli Protein-Like; Adenomatous Polyposis Coli Protein 2; APC-Like; APC2, ANAPHASE-PROMOTING COMPLEX/CYCLOSOME 2, APC2. |
| UniProt ID | Q8H1U5 |
See other products for " apc2 "
| CBMOAB-66104FYA | Mouse Anti-Zebrafish apc2 Antibody (CBMOAB-66104FYA) |
| CBMOAB-00246CR | Mouse Anti-Yeast APC2 Antibody (CBMOAB-00246CR) |
| CBMOAB-35988FYA | Mouse Anti-Rhesus APC2 Antibody (CBMOAB-35988FYA) |
| CBMOAB-01095FYA | Mouse Anti-D. melanogaster Apc2 Antibody (CBMOAB-01095FYA) |
| CBMOAB-00557HCB | Mouse Anti-C. elegans APC2 Antibody (CBMOAB-00557HCB) |
| CBMOAB-2256FYC | Mouse Anti-Arabidopsis APC2 Antibody (CBMOAB-2256FYC) |
| MO-AB-51067W | Mouse Anti-Marmoset APC2 Antibody (MO-AB-51067W) |
| MO-AB-23784R | Mouse Anti-Pig APC2 Antibody (MO-AB-23784R) |
| MO-AB-03375W | Mouse Anti-Rhesus APC2 Antibody (MO-AB-03375W) |
| MO-AB-00070H | Mouse Anti-Arabidopsis APC2 Antibody (MO-AB-00070H) |
For Research Use Only | Not For Clinical Use.
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