Mouse Anti-Atg14 Antibody (CBMOAB-01989FYA)


Cat: CBMOAB-01989FYA
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Lot Number

  • Product List
  • Specifications
  • Application Information
  • Target
Sub Cat Clonality Species Reactivity Application Clone Conjugate Size  
CBMOAB-01989FYA Monoclonal Fruit fly (Drosophila melanogaster), Marmoset WB, ELISA MO01989FYA 100 µg
MO-AB-51460W Monoclonal Marmoset WB, ELISA MO51460W 100 µg

Specifications

Host speciesMouse (Mus musculus)
Species ReactivityFruit fly (Drosophila melanogaster), Marmoset
CloneMO01989FYA
SpecificityThis antibody binds to fruit fly Atg14.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionRequired for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity).
Product OverviewMouse Anti-D. melanogaster Atg14 Antibody is a mouse antibody against Atg14. It can be used for Atg14 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesCG11877; LD37690p; Atg14
UniProt IDQ9VAP6
Protein RefseqThe length of the protein is 503 amino acids long.
The sequence is show below: MANSSSSDESCKAPDNFRISSASTNGEDEESDVAGYTTKRRPTAATKELLKDANAKDRNATTGMGAHMRCPLCHSCSASRFHCRNCVRNGNITHSQAERPESLTEKQQRYINLQAGLKTFSTRYERLIGQHRSNEDRLMAIKAKRKQLELLQQLISGTGQRLRVLGERRDELRRANAEKRKNLPKYPDKVKMLENYVLDRVEKIEKLRETHLGLLDSIKQAARRSIQQLVTYVFPIAEVVLKEEQQRRASVERTEEAETIAALADAKNTSYIRGKWVFHGSGISEVQYRIVGPSLPANGDYTAYLDWLADNKDDVPKATANEITPSRFEAYRIVGALTYTAQLTQLLSFYLNVRLPHKIAYGDFCRKLLNEEQFRRKISRLNSNIMYLAYTQQVKLRALIEQHTLENLLAILDLERSDLGRYGHLDVNNAPLMKSVDSLLIGIETATESESEDENSLRMDWEAVPSLTPQPELADPNLMPAANQQSTIAFVRMAATSVLRWIK.
For Research Use Only | Not For Clinical Use.
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