Mouse Anti-ATX3 Antibody (CBMOAB-00815HCB)

Cat: CBMOAB-00815HCB

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Lot Number

Product List
Specifications
Application Information
Target

Sub Cat	Clonality	Species Reactivity	Application	Clone	Conjugate	Size
CBMOAB-00815HCB	Monoclonal	C. elegans (Caenorhabditis elegans), A. thaliana (Arabidopsis thaliana)	WB, ELISA	MO00815HB		100 µg	Inquiry
Protein Refseq: The length of the protein is 317 amino acids long. The sequence is show below: MSKDDPINSIFFEHQEAALCAQHALNMLLQDALYKWQDLRDLAIQMDKMEQQILGNANPTPGRSENMNESGYFSIQVLEKALETFSLKLTNIENPAMVDYKNNPLTARAYICNLREHWFVLRKFGNQWFELNSVNRGPKLLSDTYVSMFLHQVSSEGYSIFVVQGVLPRSDADDLISLCPVVPPKVTPKKEQKLEKVMTKFFNTVGKRLGGGSGAPPDSQEEKDLAIAFAMSMETKDGSEVSRSSAEIDEENLRKAIELSQAPGPSEPAEIPLLTRSRSSTPPGASEPFSNAEQQRRDRQKFLERFEKKKEERNDEK.
CBMOAB-24941FYC	Monoclonal	A. thaliana (Arabidopsis thaliana)	WB, ELISA	MO24941FC		100 µg	Inquiry
Protein Refseq: The length of the protein is 1018 amino acids long. The sequence is show below: MILKRTLTTFENQNLKRCKIDSEIEYGRKKGEIIVYKKRQRATVDQPCSKEPELLTSSSSSLTSKEESQQVCSDQSKSSRGRVRAVPSRFKDSIVGTWKSSRRKGESTESSHDDDDVSLGKKVKGFSGSSKLHRSKDSKVFPRKDNGDSSEVDCDYWDVQISYDDANFGMPKKSDASRKGVYKPEEFTVGDLVWAKCGKRFPAWPAVVIDPISQAPDGVLKHCVPGAICVMFFGYSKDGTQRDYAWVRQGMVYPFTEFMDKFQDQTNLFNYKASEFNKALEEAVLAENGNFGDAEIISPDSSATESDQDYGPASRFQGSYHEDIRTCDGCGSVMPLKSLKRTKDSQPEELLCKHCSKLRKSNQYCGICKRIWHPSDDGDWVCCDGCDVWVHAECDNITNERFKELEHNNYYCPDCKVQHELTPTILEEQNSVFKSTEKTTETGLPDAITVVCNGMEGTYIRKFHAIECKCGSCGSRKQSPSEWERHTGCRAKKWKYSVRVKDTMLPLEKWIAEFSTYTLETQMLDKQKMLSLLEEKYEPVRAKWTTERCAVCRWVEDWEENKMIICNRCQVAVHQECYGVSKSQDLTSWVCRACETPDIERDCCLCPVKGGALKPSDVEGLWVHVTCAWFRPEVGFLNHENMEPAVGLFKIPANSFLKVCTICKQTHGSCVHCCKCATHFHAMCASRAGYNMELHCLEKNGVQRTRKSVYCSFHRKPDPDSVVVVHTPSGVFGSRNLLQNQYGRAKGSRLVLTKKMKLPGFQTQTQAEQSRVFDSLSAARCRIYSRSNTKIDLEAISHRLKGPSHHSLSAIENLNSFKASFSFRAPFMSVFCFLGATFSEYLRKILISIYLVTHQEADFTSFRERLKHLQRTENFRVCFGKSGIHGWGLFARKSIQEGEMIIEYRGVKVRRSVADLREANYRSQGKDCYLFKISEEIVIDATDSGNIARLINHSCMPNCYARIVSMGDGEDNRIVLIAKTNVAAGEELTYDYLFEVDESEEIKVPCLCKAPNCRKFMN.

Specifications

Host species	Mouse (Mus musculus)
Species Reactivity	C. elegans (Caenorhabditis elegans), A. thaliana (Arabidopsis thaliana)
Clone	MO00815HB
Specificity	This antibody binds to C. elegans ATX3.
Format	Liquid or Lyophilized
Storage	Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use
Purity	> 90% was determined by SDS-PAGE
Purification	Purified with Protein A or G affinity chromatography
Cellular Localization	Nucleus; Other locations

Application Information

Application	WB, ELISA
Application Notes	ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

Introduction	Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway (PubMed:19545544, PubMed:17234717, PubMed:21317884). Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan (PubMed:21317884). Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci (PubMed:27669035). Interacts with key regulators of transcription and represses transcription (By similarity). Acts as a histone-binding protein that regulates transcription (By similarity).
Product Overview	Mouse Anti-C. elegans ATX3 Antibody is a mouse antibody against ATX3. It can be used for ATX3 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative Names	Ataxin-3 homolog; EC 3.4.19.12; Machado-Joseph disease-like protein; atx-3
UniProt ID	O17850
Protein Refseq	The length of the protein is 317 amino acids long. The sequence is show below: MSKDDPINSIFFEHQEAALCAQHALNMLLQDALYKWQDLRDLAIQMDKMEQQILGNANPTPGRSENMNESGYFSIQVLEKALETFSLKLTNIENPAMVDYKNNPLTARAYICNLREHWFVLRKFGNQWFELNSVNRGPKLLSDTYVSMFLHQVSSEGYSIFVVQGVLPRSDADDLISLCPVVPPKVTPKKEQKLEKVMTKFFNTVGKRLGGGSGAPPDSQEEKDLAIAFAMSMETKDGSEVSRSSAEIDEENLRKAIELSQAPGPSEPAEIPLLTRSRSSTPPGASEPFSNAEQQRRDRQKFLERFEKKKEERNDEK.

For Research Use Only | Not For Clinical Use.

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