Mouse Anti-ATXN2 Antibody (CBMOAB-36633FYA)

Cat: CBMOAB-36633FYA

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Lot Number

Product List
Specifications
Application Information
Target

Sub Cat	Clonality	Species Reactivity	Application	Clone	Conjugate	Size
CBMOAB-36633FYA	Monoclonal	Rhesus (Macaca mulatta), Frog (Xenopus laevis), Zebrafish (Danio rerio)	WB, ELISA	MO36633FYA		100 µg	Inquiry
Protein Refseq: The length of the protein is 416 amino acids long. The sequence is show below: MRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGELTANEELEALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSCSDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSGGR.
CBMOAB-67218FYA	Monoclonal	Zebrafish (Danio rerio)	WB, ELISA	MO67218FYA		100 µg	Inquiry
Protein Refseq: The length of the protein is 1112 amino acids long. The sequence is show below: MSMKPQAGGNRKPGGSNSGAAAASGTGGAGGGVGRQNMGRGRNNAKGPSTAVAFNGVYANMRMVHVLTSVVGTKCELKVKNGLIYEGVFKTYGPECDIVLDAAHRKSVEPNAGPRREDIVESIIFKSSDVVVVHFKDVDLNYAKKDNFTDSAVSARVNGEHKEKDLEPWDGGEQHISGSMESLDTDLSNGWDPDEMFKYNEETYGVKSTYDSSLSSYTVPLERDNSEEFLKREARASQLAEEIEASATYKARVALENDDRSEEEKYTAVVRGERELHSLNRENKYIPPSQRNREAGMSWGAGRQVSPRLVQCSSGPPTPRSGPHDYNTIDQRVVNGGAQPWPSRCPSPSSRPPSRYQSGPTNSLPPRAATPTRPPSRPPSRPSRPLSHPSAHGTSGPLSNMPKRLSSEGPPRMSPKSQRTPRPHRVASCRGGGPPPSDYMSQGASVEVSAPPPTRNSPSGGTWSSVVSGAHRPRSPRQNSIGGEAPNSSCLSSPQAGTVPVDSVTASTTATSPTAANPATNLEASPIEEAKESRVLETRQNSPNANKENVKPIEASPGIARSIGKGSPSMASDHRKQIDNLKKFSAAFRLQPSSSSDPGFEAMGTKPPRDLGEKPKDQAAEKGSVDSTGLKASTESSISEETSSPVSVTSAGSKAGTPSLSPSSAVPEQKRGPDVTSQGVQTTSPLANAVTKDKDEKEDKNDPVAESVRKSTLNPNAKEFNPRVFCSPPKPATTPTLTRPQGQPSPSIVVQQPPTVYGQTMFQMYPLTPVSPGVQPPAMYHVQVPHMTMSQTKSYRSGKVQNMPQQRPDQHHPPGTSTMMHSATAAGPPIVAPSPAYSTQYFTCSPQQFASQPLVQQMPHYQSQAQHVFSPVIQGSARMITPPTHAQPSLVSSSTTQYGEQTHTMYGKNFPSTMTKLNKPTYSTPIPQQFPHPSSTLHPHPQHPQPSATPTGQPQQGTQHGGSHPAPSPVQHQQHQAAAAAAAQAIHLGNPQQQQMYSALAATPPSMTPGPNPQSPQASFPSAQQAVYIHPQHGYNPNHMAHVQQAHMQSGMVPPHHGNPSHPPTMMLMATQAPAGPQPALPQGTLNPIPVSSGTHFYSTLTPVQAHHQQQL.
MO-AB-01759H	Monoclonal	Frog (Xenopus laevis)	WB, ELISA	MO01759C		100 µg	Inquiry
Protein Refseq: The length of the protein is 630 amino acids long. The sequence is show below: MSMKQQAGNNRKPGGGSVPAAGGGAGGGRQNMGRGRISGKGPPQSISFDGIYANMRLVHILTSVVGSKCEVLVKNGNVYEGVFKTYSPKCDLVLDAAHKKTTESIVGPKREDIVDSILFKSSDFVMVQFKDMDVNYARRDGFTDSGIACRLNGEHKEKDLEPWDGGESLISSTPTGKDELESLENESNGWDPNEMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEYLKREARAAQIAEEIESSSQYKARVALENDERSEEEKYTAVQRALNDQERHSLNTRENKYIPPVQRNKDAMLWTTHSGRQNSARIGQSGSGPIPSRTGSHSSDYNPNAGADQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRTHRVSNGRGTMCGGLEFVSRNEAGEASVQPVARNSSSGGTWSSVVSGVQRLSPKTHRPRSPRLGSHAPGSNATSPQPGTVPPESVSMPVPAASPTPASPASDRAVTPSCEAKDTRLQDQRQNSPAGCRENSKYSESSKTENKAVSPMASEQRKQLDDLKKFKNDFRLQPSSSPDALDQLPVKSRDSVEKPRDPLKKKNGFKC.

Specifications

Host species	Mouse (Mus musculus)
Species Reactivity	Rhesus (Macaca mulatta), Frog (Xenopus laevis), Zebrafish (Danio rerio)
Clone	MO36633FYA
Specificity	This antibody binds to Rhesus ATXN2.
Format	Liquid or Lyophilized
Storage	Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use
Purity	> 90% was determined by SDS-PAGE
Purification	Purified with Protein A or G affinity chromatography

Application Information

Application	WB, ELISA
Application Notes	ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

Introduction	This gene belongs to a group of genes that is associated with microsatellite-expansion diseases, a class of neurological and neuromuscular disorders caused by expansion of short stretches of repetitive DNA. The protein encoded by this gene has two globular domains near the N-terminus, one of which contains a clathrin-mediated trans-Golgi signal and an endoplasmic reticulum exit signal. The encoded cytoplasmic protein localizes to the endoplasmic reticulum and plasma membrane, is involved in endocytosis, and modulates mTOR signals, modifying ribosomal translation and mitochondrial function. The N-terminal region of the protein contains a polyglutamine tract of 14-31 residues that can be expanded in the pathogenic state to 32-200 residues. Intermediate length expansions of this tract increase susceptibility to amyotrophic lateral sclerosis, while long expansions of this tract result in spinocerebellar ataxia-2, an autosomal-dominantly inherited, neurodegenerative disorder. Genome-wide association studies indicate that loss-of-function mutations in this gene may be associated with susceptibility to type I diabetes, obesity and hypertension. Alternative splicing results in multiple transcript variants.
Product Overview	Mouse Anti-Rhesus ATXN2 Antibody is a mouse antibody against ATXN2. It can be used for ATXN2 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative Names	ATXN2
UniProt ID	F6UKC2
Protein Refseq	The length of the protein is 416 amino acids long. The sequence is show below: MRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGELTANEELEALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSCSDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSGGR.

For Research Use Only | Not For Clinical Use.

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