Mouse Anti-Atxn7 Antibody (CBMOAB-02085FYA)

Cat: CBMOAB-02085FYA

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Lot Number

Product List
Specifications
Application Information
Target

Sub Cat	Clonality	Species Reactivity	Application	Clone	Conjugate	Size
CBMOAB-02085FYA	Monoclonal	Fruit fly (Drosophila melanogaster), Frog (Xenopus laevis), Rhesus (Macaca mulatta)	WB, ELISA	MO02085FYA		100 µg	Inquiry
Protein Refseq: The length of the protein is 971 amino acids long. The sequence is show below: MPLNDVAPAGGGAYPENGTKHKVSGMWKPDSSAGSNSGSGSAGLSLFSLQGQKWQQVFDMEKVIKQLRTAEKTYLRGGKNSSAGADQQAKVQVQRLQSADMAYYDLAPKLASRDIVLCSSCSGCYTKAGFQHHIALQHPSVWEATSSKVNPNPNGTAISSDSRLTATEISQEGGAIVPSSPTDTLSASTLSSCSNGSSSSASLQHPAAAGSSSTTSSSSSSRHKSSSSKSSSSSSSKGSSSTSAGSRSRSKSSKNRHHSSPAPALLESNHKESKGSKKSSAIAAPPVVAAVVKEEPPSVGAAPAAITMFSSSSNSSCSLPPTPTLGAASSEVAMGVNYSPAQLQTDAEKLPELQPKKKLKGSSDHRIKAEKEKNKDKSLVNSYEQQQVLSELDQAVSSITGAVSAEQVAPDEEELPLPNTSDENSISQTLDEMLDSKLINEILNNFDESALDTSQQQSQQQAQNGSLSHPAQATKRLRFEDGTIGEDYAVYQQQAVQQVYGEEEHQQELTTIDAMQLQQLIYQQQQMLEQQQLQEQQQQQQQDQKLQDHEQQRQFSVYNVPSLTDEAMVNPQQQQLEEHMILPSIIYEITESNPVSMLEQKVLAEFLTNAGYENVDVNVVQSGGIQTNLSSGTEANQLADELADFEFSKLETVSDTVKTVKLEAKAASQPPTTNPQINHHPSLANAKYHEDSYFNVMLYSGAPRPLAMNTFGMVKLPQGLGVTFRKNLLTTRKANNNLLSLSGGNHLGVVGQLARTPPPPSPALSNGLPGKNPASGRTIYAQRSNVIAQDRLRCNKRALVGGKAGGGSSGSPGVMTAKRLNELLMGKAKKEEKPPPDSEDGGEQPTKDKERDKEEDNKLTFSFYEKRRRLLAGKLEQLQPLGRPSFTLPLQSNHNASQSQSHSPQQLLKKQLLRTLSDSSSNMNISNMNNISNLNSSNTPSANSNPPWKGNSSNPGGNSTPTSSDLMRVFV.
CBMOAB-36641FYA	Monoclonal	Rhesus (Macaca mulatta)	WB, ELISA	MO36641FYA		100 µg	Inquiry
Protein Refseq: The length of the protein is 552 amino acids long. The sequence is show below: MSERAADDVRGEPRRAAAAGGAAAAAARQQQQQPPQPQRQQQPPPPPPRRPRPEDCGPGAASTSAAAMATVGERRPLPSPEVMLGQSWNLWVEASKLPGKDGTELDESFKEFGKNREVMGLCREDMPIFGFCPAHDDFYLVVCNDCNQVVKPQAFQSHYERRHSSSSKPSLAVPPTSVFSFFPSLSKSKGGSASGSNRSSSGGVLSASSSSSKLLKSPKEKLQLRGNTRPMHPIQQSRVPHGRIMTPSVKVEKIHPKMDGTLLKSAVGPTCPATVSSLVKPGLNCPSIPKPTLPSPGQILNGKGLPAPLSLEKKPEDNSNNRKFLNKRLSEREFDPDIHCGVIDLDTKKPCTRSLTCKTHSLTQRRAVQGRRKRFDVLLAEHKNKTREKELIRHPDSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPFVASKPKPHTPSLPRPPGCPAQQGSAPIEPPVHESPHPPLPATEPASRLSSEEGEGDDKEESVEKLDCHYSGHHPQPASFCTFGSRQIGRGYYVFDSRWNRLRCALNLMVEKHLNAQLWK.
MO-AB-01224W	Monoclonal	Rhesus (Macaca mulatta)	WB, ELISA	MO01224W		100 µg	Inquiry
Protein Refseq: The length of the protein is 811 amino acids long. The sequence is show below: RPLPSPEVMLGQSWNLWVEASKLPGKDGTELDESFKEFGKNREVMGLCREDMPIFGFCPAHDDFYLVVCNDCNQVVKPQAFQSHYERRHSSSSKPSLAVPPTSVFSFFPSLSKSKGGSASGSNRSSSGGVLSASSSSSKLLKSPKEKLQLRGNTRPMHPIQQSRVPHGRIMTPSVKVEKIHPKMDGTLLKSAVGPTCPATVSSLVKPGLNCPSIPKPTLPSPGQILNGKGLPAPLSLEKKPEDNSNNRKFLNKRLSEREFDPDIHCGVIDLDTKKPCTRSLTCKTHSLTQRRAVQGRRKRFDVLLAEHKNKTREKELIRHPDSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPFVASKPKPHTPSLPRPPGCPAQQGGSAPIDPPPVHESPHPPLPATEPASRLSSEEGEGDDKEESVEKLDCHYSGHHPQPASFCTFGSRQIGRGYYVFDSRWNRLRCALNLMVEKHLNAQLWKKIPPVPSTTSPISTRIPQRTNSVPTSQCGVSYLAAATVSTSPVLLSSTCISPNSKSVPAHGTTLNAQPAASGAMDPVCSMQSRQVSSSSSSPSTPSGLSSVPSSPMSRKPQKLKSSKSLRPKESSGNSTNCQNASSSTSGGSGKKRKNTSPLLVHSSSSSSSSSSSSHSMESFRKNCVAHSGPPYPSTVTSSHSIGLNCVTNKANAVNVRHDQSGRGPPSGSPAESIKRMSVMVNSSDSTLSLGPFIHQSNELPVNSHGSFSHSHTPLDKLIGKKRKCSPSSSSINNSSSKPTKVAKVPAMNNVHMKHTGTIAGAQGLTNNSLLHQPKARP.
MO-AB-01761H	Monoclonal	Frog (Xenopus laevis)	WB, ELISA	MO01761C		100 µg	Inquiry
Protein Refseq: The length of the protein is 825 amino acids long. The sequence is show below: MSERAEDDVTGEQQQRRAAVRQQQRRQQQGESSAATMAAGGDRTSLPSPGAMLGQPWAHWVDTVKLNGLEELEESWKECDKKREAMRLSKEDMAIFGLCPAYDEFYLVMCSHCNQAIKPQAFQSHYERRHSSINKTPVTPPSSSMNSLYSTVSSKTKPSGGGCSITRPPARSSASSNSKLMKSPKDKLQIGGSNRSMHPVQHSKAPQEKTMTPSVKVEKIHPNPKIDGMLKSTAGPACSSTVSSSIKTGLNCPSIPKPPLPSPGHIPNGKGILSTTPFSEKKPDDTNNRKYLHKRLSDREFDPDIHCGVVDVETKKPCTRSLTCKTHSLGYRRAVQGRKKRFDVLLAEHKNKTREKELLRHSEHQQQAPALREPHPLPSKSSQELHQNSHGLTSPEAKTSITNKAKPHNSSLPRPSVYPATHSGNAPSDSPSLHESPQPVVSAAEPNCRLSSDEGEGDEKEESAEKLDCHYSDHHPRPAAYCTFGSRQIGRGYYVFDKRWDHIRCALNFMVDKHLNSQMWRKIPPASSNLSHRSSTNATSVSHGVTGFLSPSTMTSPSVTAASPCASLDKVSSHGTTLNAHPVGASDSASSMQSRQVSSSPSTPSVLSPVPSPHSNKPQKLKTPKSLKPKETPASSTNCSSIGGGSGKKRKTSSPPQLLAHPPHSTESVRKNCALNSGTHHS.

Specifications

Host species	Mouse (Mus musculus)
Species Reactivity	Fruit fly (Drosophila melanogaster), Frog (Xenopus laevis), Rhesus (Macaca mulatta)
Clone	MO02085FYA
Specificity	This antibody binds to fruit fly Atxn7.
Format	Liquid or Lyophilized
Storage	Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use
Purity	> 90% was determined by SDS-PAGE
Purification	Purified with Protein A or G affinity chromatography
Cellular Localization	Nucleus; Other locations

Application Information

Application	WB, ELISA
Application Notes	ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

Introduction	The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the 'pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with spinocerebellar ataxia-7 contains 37-306 CAG repeats (near the N-terminus), compared to 4-35 in the normal allele. The encoded protein is a component of the SPT3/TAF9/GCN5 acetyltransferase (STAGA) and TBP-free TAF-containing (TFTC) chromatin remodeling complexes, and it thus plays a role in transcriptional regulation. Alternative splicing results in multiple transcript variants.
Product Overview	Mouse Anti-D. melanogaster Atxn7 Antibody is a mouse antibody against Atxn7. It can be used for Atxn7 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative Names	Ataxin 7, isoform A; Ataxin 7, isoform B; Ataxin 7, isoform C; Ataxin 7, isoform D; LD40170p; Atxn7
UniProt ID	Q9VQB6
Protein Refseq	The length of the protein is 971 amino acids long. The sequence is show below: MPLNDVAPAGGGAYPENGTKHKVSGMWKPDSSAGSNSGSGSAGLSLFSLQGQKWQQVFDMEKVIKQLRTAEKTYLRGGKNSSAGADQQAKVQVQRLQSADMAYYDLAPKLASRDIVLCSSCSGCYTKAGFQHHIALQHPSVWEATSSKVNPNPNGTAISSDSRLTATEISQEGGAIVPSSPTDTLSASTLSSCSNGSSSSASLQHPAAAGSSSTTSSSSSSRHKSSSSKSSSSSSSKGSSSTSAGSRSRSKSSKNRHHSSPAPALLESNHKESKGSKKSSAIAAPPVVAAVVKEEPPSVGAAPAAITMFSSSSNSSCSLPPTPTLGAASSEVAMGVNYSPAQLQTDAEKLPELQPKKKLKGSSDHRIKAEKEKNKDKSLVNSYEQQQVLSELDQAVSSITGAVSAEQVAPDEEELPLPNTSDENSISQTLDEMLDSKLINEILNNFDESALDTSQQQSQQQAQNGSLSHPAQATKRLRFEDGTIGEDYAVYQQQAVQQVYGEEEHQQELTTIDAMQLQQLIYQQQQMLEQQQLQEQQQQQQQDQKLQDHEQQRQFSVYNVPSLTDEAMVNPQQQQLEEHMILPSIIYEITESNPVSMLEQKVLAEFLTNAGYENVDVNVVQSGGIQTNLSSGTEANQLADELADFEFSKLETVSDTVKTVKLEAKAASQPPTTNPQINHHPSLANAKYHEDSYFNVMLYSGAPRPLAMNTFGMVKLPQGLGVTFRKNLLTTRKANNNLLSLSGGNHLGVVGQLARTPPPPSPALSNGLPGKNPASGRTIYAQRSNVIAQDRLRCNKRALVGGKAGGGSSGSPGVMTAKRLNELLMGKAKKEEKPPPDSEDGGEQPTKDKERDKEEDNKLTFSFYEKRRRLLAGKLEQLQPLGRPSFTLPLQSNHNASQSQSHSPQQLLKKQLLRTLSDSSSNMNISNMNNISNLNSSNTPSANSNPPWKGNSSNPGGNSTPTSSDLMRVFV.

For Research Use Only | Not For Clinical Use.

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