Mouse Anti-BRCA1 Antibody (CBMOAB-25468FYC)


Cat: CBMOAB-25468FYC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

  • Product List
  • Specifications
  • Application Information
  • Target
Sub Cat Clonality Species Reactivity Application Clone Conjugate Size  
CBMOAB-25468FYC Monoclonal A. thaliana (Arabidopsis thaliana), Cattle (Bos taurus), Chicken (Gallus gallus), Chimpanzee (Pan troglodytes), Dog (Canis lupus familiaris), Donkey (Equus asinus), Ferret (Mustela Putorius Furo), Frog (Xenopus laevis), Hamsters (Cricetinae), Horse (Equus caballus), Marmoset, Pig (Sus scrofa), Purple sea urchin (Strongylocentrotus purpuratus), Rabbit (Oryctolagus cuniculus), Rhesus (Macaca mulatta), Sheep (Ovis aries) WB, ELISA MO25468FC 100 µg
CBMOAB-37078FYA Monoclonal Rhesus (Macaca mulatta) WB, ELISA MO37078FYA 100 µg
MO-AB-00898Y Monoclonal Chicken (Gallus gallus) WB, ELISA MO00898Y 100 µg
MO-AB-01319W Monoclonal Rhesus (Macaca mulatta) WB, ELISA MO01319W 100 µg
MO-AB-01921H Monoclonal Frog (Xenopus laevis) WB, ELISA MO01921C 100 µg
MO-AB-07366Y Monoclonal Rabbit (Oryctolagus cuniculus) WB, ELISA MO07366Y 100 µg
MO-AB-09116R Monoclonal Cattle (Bos taurus) WB, ELISA MO09116R 100 µg
MO-AB-14401Y Monoclonal Sheep (Ovis aries) WB, ELISA MO14401Y 100 µg
MO-AB-15024W Monoclonal Chimpanzee (Pan troglodytes) WB, ELISA MO15024W 100 µg
MO-AB-24182R Monoclonal Pig (Sus scrofa) WB, ELISA MO24182R 100 µg
MO-AB-29265W Monoclonal Dog (Canis lupus familiaris) WB, ELISA MO29265W 100 µg
MO-AB-30602H Monoclonal Purple sea urchin (Strongylocentrotus purpuratus) WB, ELISA MO30602C 100 µg
MO-AB-34168W Monoclonal Donkey (Equus asinus) WB, ELISA MO34168W 100 µg
MO-AB-34462W Monoclonal Ferret (Mustela Putorius Furo) WB, ELISA MO34462W 100 µg
MO-AB-42966W Monoclonal Hamsters (Cricetinae) WB, ELISA MO42966W 100 µg
MO-AB-43866W Monoclonal Horse (Equus caballus) WB, ELISA MO43866W 100 µg
MO-AB-51933W Monoclonal Marmoset WB, ELISA MO51933W 100 µg

Specifications

Host speciesMouse (Mus musculus)
Species ReactivityA. thaliana (Arabidopsis thaliana), Cattle (Bos taurus), Chicken (Gallus gallus), Chimpanzee (Pan troglodytes), Dog (Canis lupus familiaris), Donkey (Equus asinus), Ferret (Mustela Putorius Furo), Frog (Xenopus laevis), Hamsters (Cricetinae), Horse (Equus caballus), Marmoset, Pig (Sus scrofa), Purple sea urchin (Strongylocentrotus purpuratus), Rabbit (Oryctolagus cuniculus), Rhesus (Macaca mulatta), Sheep (Ovis aries)
CloneMO25468FC
SpecificityThis antibody binds to Arabidopsis BRCA1.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationNucleus; Plasma Membrane

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionThis gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
Product OverviewMouse Anti-Arabidopsis BRCA1 Antibody is a mouse antibody against BRCA1. It can be used for BRCA1 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesBRCA1, DNA Repair Associated; Protein Phosphatase 1, Regulatory Subunit 53; BRCA1/BRCA2-Containing Complex, Subunit 1; Fanconi Anemia, Complementation Group S; Breast Cancer 1, Early Onset; RING Finger Protein 53; RNF53; Breast And Ovarian Cancer Susceptibility Protein 1; Breast Cancer Type 1 Susceptibility Protein; RING-Type E3 Ubiquitin Transferase BRCA1; Early Onset Breast Cancer 1; Breast Cancer 1
UniProt IDQ8RXD4
Protein RefseqThe length of the protein is 941 amino acids long. The sequence is show below: MADTSHLERMGRELKCPICLSLYNSAVSLSCNHVFCNACIVKSMKMDATCPVCKIPYHRREIRGAPHMDSLVSIYKNMEDASGIKLFVSQNNPSPSDKEKQVRDASVEKASDKNRQGSRKGRASKRNEYGKTKEIDVDAPGPIVMKPSSQTKKRVQLLQNLSAESLTKPTESVETAEKPKDYTENTVIRLDEHPSLNKEGNLSPFFWLRDEDDGENSSQRTESDQLLGTTPVNVPSFSDLMDSDHESPSKEDEQQKPNPGDMFDSEMFEWTQRPCSPEILPSPVKAKVLGRDEIDLTQKKLPKVKVASSKCKNRKAGSARNTVARRSIGVSQEDNMESSAAATISEQQDSRGTSGTIIRNDVNTDENVKAKRATRSKAQSTRVQSDLNVSNEADGKQGTKRKRSSIKSSPAHPIAGPNELSLGTEIVGKGDQDQAHGPSDTHPEKRSPTEKPSLKKRGRKSNASSSLKDLSGKTQKKTSEKKLKLDSHMISSKATQPHGNGILTAGLNQGGDKQDSRNNRKSTVGKDDHTMQVIEKCSTINKSSSGGSAHLRRCNGSLTKKFTCAFCQCSEDTEASGEMTHYYRGEPVSADFNGGSKVIHVHKNCAEWAPNVYFNDLTIVNLDVELTRSRRISCSCCGLKGAALGCYNKSCKNSFHVTCAKLIPECRWDNVKFVMLCPLDASIKLPCEEANSKDRKCKRTPKEPLHSQPKQVSGKANIRELHIKQFHGFSKKLVLSCSGLTVEEKTVIAEFAELSGVTISKNWDSTVTHVIASINENGACKRTLKFMMAILEGKWILTIDWIKACMKNTKYVSEEPYEITMDVHGIREGPYLGRQRALKKKPKLFTGLKFYIMGDFELAYKGYLQDLIVAAGGTILRRRPVSSDDNEASTIVVFSVEPSKKKTLTQRRSDAEALAKSARARAASSSWVLDSIAGCQILVLI.
For Research Use Only | Not For Clinical Use.
Online Inquiry