Mouse Anti-C. elegans AIR2 Antibody (CBMOAB-00453HCB)
Cat: CBMOAB-00453HCB
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- Product Details
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | C. elegans (Caenorhabditis elegans) |
| Clone | MO00453HB |
| Specificity | This antibody binds to C. elegans AIR2. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
| Cellular Localization | Nucleus; Cytoskeleton; Other locations |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis (PubMed:12707312, PubMed:11050385, PubMed:10983970, PubMed:9852156, PubMed:10354474, PubMed:10975519, PubMed:11050384). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation (PubMed:12707312, PubMed:10983970). Required for histone H3 phosphorylation during segregation of homologous chromosomes in meiosis and mitosis (PubMed:18923084). Required for histone H3 'Ser-10' phosphorylation (PubMed:9852156, PubMed:10354474, PubMed:10975519, PubMed:11050384, PubMed:11050385, PubMed:10983970, PubMed:12015116, PubMed:11940606). Phosphorylates tlk-1 at 'Ser-634', which enhances its activity (PubMed:15916946). Phosphorylates zen-4 at 'Ser-680'(PubMed:15854913). Required for the recruitment of bub-1 to the ring-shaped domain between chromosomes during meiotic anaphase I (PubMed:20729837). Also required for the localization of the condensin I complex subunit smc-4 to mitotic chromosomes (PubMed:11914278). Acts at the spindle midzone and the midbody to prevent cleavage furrow regression upon chromatin obstructions during cytokinesis (PubMed:12213836, PubMed:23684975). |
| Product Overview | Mouse Anti-C. elegans AIR2 Antibody is a mouse antibody against AIR2. It can be used for AIR2 detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Aurora / IPL1-related protein kinase 2; EC 2.7.11.1; Serine / threonine-protein kinase aurora-B; air-2 |
| Gene ID | 172268 |
| UniProt ID | O01427 |
| Protein Refseq | The length of the protein is 305 amino acids long. The sequence is show below: MENKPPVINLPEKETVNTPQKGGKFTINDFEIGRPLGKGKFGSVYLARTKTGHFHVAIKVLFKSQLISGGVEHQLEREIEIQSHLNHPNIIKLYTYFWDAKKIYLVLEYAPGGEMYKQLTVSKRFSEPTAAKYMYEIADALSYCHRKNVIHRDIKPENLLIGSQGELKIGDFGWSVHAPSNKRQTMCGTMDYLPPEMVNGADHSDAVDLWAIGVLCYEFLVGKPPFEHEDQSKTYAAIKAARFTYPDSVKKGARDLIGRLLVVDPKARCTLEQVKEHYWIQGMMEAKIRAEKQQKIEKEASLRNH. |
See other products for " AIR2 "
| CBMOAB-00197CR | Mouse Anti-Yeast AIR2 Antibody (CBMOAB-00197CR) |
For Research Use Only | Not For Clinical Use.
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