Cat: CBMOAB-00096HCB
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- Product Details
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | C. elegans (Caenorhabditis elegans) |
| Clone | MO00096HB |
| Specificity | This antibody binds to C. elegans LGG1. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
| Cellular Localization | Nucleus; Cytosol; Plasma membrane; Other locations; Lysosome; Mitochondrion |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes) (PubMed:26687600). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion during autophagy (PubMed:26687600, PubMed:21802374). Recruits lipidated-lgg-2 to maturing autophagosomes (PubMed:12958363, PubMed:20523114, PubMed:26687600). Acts in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation (PubMed:26687600). In particular, binds to components of the unc-51-atg-13 complex to regulate autophagosome formation and cargo sequestration (PubMed:26687600). Required for the degradation of specific sepa-1- and sqst-1-containing protein aggregates during embryogenesis (PubMed:26687600). Involved in allophagy, which is an autophagic process in which paternal mitochondria and organelles are degraded during fertilization, and moreover is required for the formation of lgg-2-positive allophagic autophagosomes in embryos (PubMed:24374177). Involved in the clearance of apoptotic cells by promoting the delivery of engulfed apoptotic cells to the lysosome (PubMed:22451698). Plays a role in the distribution and clearance of germ cell specific P-granules from somatic cells (PubMed:19167332). Also plays a role in the autophagy-mediated degradation of ribosomal RNA and ribosomal proteins in lysosomes (PubMed:30102152). Required for normal survival when exposed to pathogenic bacteria S.typhimurium probably by promoting autophagic degradation of intracellular S.typhimurium (PubMed:19667176). Plays a role in mitophagy (PubMed:25896323). Essential for dauer development and life-span extension (PubMed:12958363, PubMed:20523114). |
| Product Overview | Mouse Anti-C. elegans LGG1 (clone MO00096HB) Antibody (CBMOAB-00096HCB) is a mouse antibody against LGG1. It can be used for LGG1 detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Protein lgg-1; lgg-1 |
| Gene ID | 174050 |
| UniProt ID | Q09490 |
| Protein Refseq | The length of the protein is 123 amino acids long. The sequence is show below: MKWAYKEENNFEKRRAEGDKIRRKYPDRIPVIVEKAPKSKLHDLDKKKYLVPSDLTVGQFYFLIRKRIQLRPEDALFFFVNNVIPQTMTTMGQLYQDHHEEDLFLYIAYSDESVYGGEVEKKE. |
Reference
For Research Use Only | Not For Clinical Use.