Mouse Anti-C. elegans LGG2 Antibody (CBMOAB-05962HCB)

Cat: CBMOAB-05962HCB

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Specifications
Application Information
Target

Specifications

Host species	Mouse (Mus musculus)
Species Reactivity	C. elegans (Caenorhabditis elegans)
Clone	MO05962HB
Specificity	This antibody binds to C. elegans LGG2.
Format	Liquid or Lyophilized
Storage	Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use
Purity	> 90% was determined by SDS-PAGE
Purification	Purified with Protein A or G affinity chromatography
Cellular Localization	Plasma Membrane; Other locations; Cytosol

Application Information

Application	WB, ELISA
Application Notes	ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

Introduction	Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes) (PubMed:26687600). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion (PubMed:26687600). Less effective at promoting membrane fusion than lgg-1 (PubMed:26687600). Acts upstream of the autophagy protein epg-5 in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation (PubMed:26687600). In particular binds to components of an atg-5-lgg-3-atg-16 complex to regulate autophagosome formation and cargo sequestration (PubMed:26687600). Required for the degradation of specific sqst-1-containing aggregates during embryogenesis and the early stages of larval development (PubMed:26687600). Involved in allophagy, which is an autophagic process in which paternal mitochondria and organelles are degraded during fertilization, and moreover is required for the degradation of lgg-1-positive allophagic autophagosomes in embryos (PubMed:25126728, PubMed:24374177). Through HOPS complex subunit vps-39, tethers lysosomes with autophagosomes to form autolysosomes (PubMed:24374177). Plays a role in the distribution and clearance of germ cell specific P-granules from somatic cells to ensure exclusive localization of the P-granules in germ cells (PubMed:19167332). Essential for dauer development and life-span extension (PubMed:20523114).
Product Overview	Mouse Anti-C. elegans LGG2 Antibody is a mouse antibody against LGG2. It can be used for LGG2 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative Names	Protein lgg-2; lgg-2
UniProt ID	Q23536
Protein Refseq	The length of the protein is 130 amino acids long. The sequence is show below: MSGNRGGSYISGIVPSFKERRPFHERQKDVEEIRSQQPNKVPVIIERFDGERSLPLMDRCKFLVPEHITVAELMSIVRRRLQLHPQQAFFLLVNERSMVSNSMSMSNLYSQERDPDGFVYMVYTSQPAFG.

For Research Use Only | Not For Clinical Use.

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