Mouse Anti-Cattle NPC1 Antibody (MO-AB-16871R)


Cat: MO-AB-16871R
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityCattle (Bos taurus)
CloneMO16871R
SpecificityThis antibody binds to Cattle NPC1.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationOther locations; Plasma membrane; Nucleus; Endoplasmic reticulum

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionThis gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.
Product OverviewThis product is a mouse antibody against NPC1. It can be used for NPC1 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesNiemann-Pick type C1 disease protein; NPC1
UniProt IDQ9GLC9
Protein RefseqThe length of the protein is 1277 amino acids long.
The sequence is show below: MSVLGPAFGLLLLLFCPAQVFSQSCIWYGECGIASGDKRYNCRYSGPPEPLPQDGYDLVQELCPGFFFGNVSLCCDVQQLHTLKDNLQLPLQFLSRCPSCFYNLVNLFCELTCSPRQSQFLNVTATEDYVDPATNQTKTNVKELQYYVGESFANAMYNSCRDVEAPSSNEKALGLLCGREASACNATNWIEYMFNKDNGQAPFTITPVFSDLPTHGMEPMNNATKGCDESVDEVTGPCSCQDCSAVCGPKPQPPP.
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For Research Use Only | Not For Clinical Use.
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