Mouse Anti-Cytokeratin 6 Antibody (MOFY-0522-FY96)

Cat: MOFY-0522-FY96
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Host speciesMouse
Species ReactivityHuman, Zebrafish
ImmunogenMice were immunized with the carboxy-terminal peptide of cytokeratin 6.
Regulatory StatusFor Research Use Only. Not For Clinical Use.
ShippingGel Pack
StorageStore at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles.

Application Information

ApplicationIHC, FC
Application NotesThe optimal dilution should be determined by the end user.


IntroductionCytokeratins comprise a distinct group of intermediate filament proteins (IFPs), which are expressed in pairs in keratinized and non-keratinized epithelial tissues, and which constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play key roles in differentiation and tissue specialization, as well as maintaining the overall structural integrity of epithelial cells. Alpha-helical coiled coil dimers are laterally bound end-to-end to form filaments with a diameter of 10 nm. Cytokeratins are useful markers of tissue differentiation and also help characterize malignancies. IL-1 and TNFα induce the transcription of cytokeratin 6 in epidermal keratinocytes through the C/EBP β transcription factor. In humans, multiple isoforms of cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, with cytokeratin 6A being the predominant form in epithelial tissues. The gene encoding human cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are associated with several heritable hair and skin lesions.
Product OverviewMouse Anti-Cytokeratin 6 Antibody (MOF032922W267) is a Mouse antibody against Cytokeratin 6. It can be used for Cytokeratin 6 detection in Immunohistochemistry, Flow Cytometry.
Alternative NamesCytokeratin 6; Keratin K6


For Research Use Only | Not For Clinical Use.

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