Cat: MOFY-0522-FY96
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
- Product Details
Specifications
| Host species | Mouse |
| Species Reactivity | Human, Zebrafish |
| Immunogen | Mice were immunized with the carboxy-terminal peptide of cytokeratin 6. |
| Format | Liquid |
| Buffer | PBS |
| Regulatory Status | For Research Use Only. Not For Clinical Use. |
| Shipping | Gel Pack |
| Storage | Store at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles. |
Application Information
| Application | IHC, FC |
| Application Notes | The optimal dilution should be determined by the end user. |
Target
| Introduction | Cytokeratins comprise a distinct group of intermediate filament proteins (IFPs), which are expressed in pairs in keratinized and non-keratinized epithelial tissues, and which constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play key roles in differentiation and tissue specialization, as well as maintaining the overall structural integrity of epithelial cells. Alpha-helical coiled coil dimers are laterally bound end-to-end to form filaments with a diameter of 10 nm. Cytokeratins are useful markers of tissue differentiation and also help characterize malignancies. IL-1 and TNFα induce the transcription of cytokeratin 6 in epidermal keratinocytes through the C/EBP β transcription factor. In humans, multiple isoforms of cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, with cytokeratin 6A being the predominant form in epithelial tissues. The gene encoding human cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are associated with several heritable hair and skin lesions. |
| Product Overview | Mouse Anti-Cytokeratin 6 Antibody (MOF032922W267) is a Mouse antibody against Cytokeratin 6. It can be used for Cytokeratin 6 detection in Immunohistochemistry, Flow Cytometry. |
| Alternative Names | Cytokeratin 6; Keratin K6 |
Reference
For Research Use Only | Not For Clinical Use.