Mouse Anti-D. melanogaster Cic Antibody (CBMOAB-13540FYA)


Cat: CBMOAB-13540FYA
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityFruit fly (Drosophila melanogaster)
CloneMO13540FYA
SpecificityThis antibody binds to fruit fly Cic.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionThe protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Product OverviewMouse Anti-D. melanogaster Cic Antibody is a mouse antibody against Cic. It can be used for Cic detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesCG5060, isoform B; cic
UniProt IDA8JR49
Protein RefseqThe length of the protein is 683 amino acids long.
The sequence is show below: MVIPATGATIAGIPTATTTAAAESTATQQHQQHQQQQQQQQHVLFQPHLQTTTATAATCSTPQQQQPPQPRQHPKKRKFDPAELDKTEQHPQQQQQQQVSLQKQQKPAETTGNGDGLANGNQQHRMIVSCGAGAGNNSSNSSSSNNSSHSSSDIKQQQQQRIIIASPQHASGSTYKQHVASGNNSHAATINHQQRTHTPTTAVYYQQQQQQQQQQQQQRFSFNSNNQQHLQEQHQQQQQQQSLLDLSEWNNTRVLAKIQNNYAPGIIRHAQEASPDSILVEFDSTDLGLLLYTDVLHQGRNHVILDASPPMADITLDARVCVRQRVEGRGSGSFVYVEGIITDINQATKQYSVQLIGDEMATTKVVRRADLRLLQPPWWDELNELTTSGGASAPASSAKRKVPAAGAGAGTGAAGCEAMTVPSGNIVYPKTATGAPLSFVATRYDGKLPTAPPTSSHQQAQQQLSHPQQYNGLADIVISPCSNGQHLKMQQQQQQSSRGYDDYDSDDELKRVGIGYSPAAGDLDTEKMSACSKRSSMQSRGSTSSLLDQRLTPRSHPATPRSQATTPHRFKKGDIVESESGVRKKYNGKQWRRLCMLCTKESQRRGYCSRHLNQKGNTSALPSSTGPGRLLSDSRSSSKTQIDEDTSRDSETSPNYRVKGRYDQEETDAAAMLGKSLRHHHTS.
For Research Use Only | Not For Clinical Use.
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