Mouse Anti-Dog NPC1 Antibody (MO-AB-32200W)
Cat: MO-AB-32200W
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- Product Details
Specifications
Host species | Mouse (Mus musculus) |
Species Reactivity | Dog (Canis lupus familiaris) |
Clone | MO32200W |
Specificity | This antibody binds to Dog NPC1. |
Format | Liquid or Lyophilized |
Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
Purity | > 90% was determined by SDS-PAGE |
Purification | Purified with Protein A or G affinity chromatography |
Cellular Localization | Other locations; Plasma membrane; Nucleus; Endoplasmic reticulum |
Application Information
Application | WB, ELISA |
Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
Introduction | This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments. |
Product Overview | Mouse Anti-Dog NPC1 Antibody is a mouse antibody against NPC1. It can be used for NPC1 detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
Alternative Names | Niemann-Pick type C1 disease protein; NPC1 |
UniProt ID | Q9GK52 |
Protein Refseq | The length of the protein is 1276 amino acids long. The sequence is show below: MTARRPAVGLVLLLLCPAQVFAQSCVWYGECGIASGDKRYNCQYSGPPKPLPKDGYDLMQELCPGLFFDNVSVCCDVQQLRTLKDSLQLPLQFLSRCPSCFYNLMNLFCELTCSPRQSQFLNVTETEDYVDPVTNQTKTNVKELQYYVGESFANAMYNACRDVEAPSSNDKALGLLCGKEAEACNATNWIEYMFNKDNGQAPFTIIPIFSDLPAHGMKPMNNATKGCDEPVDEVTAPCSCQDCSVVCGPKPQPPPAPAPWRILGLDAMYVIMWITYMAFLLMFFGAFFAVWCYRKRYFVSEYTPIDSNIAFSVNAGDTGEASCCDALGAAFEGCLRRLFTQWGSFCIRNPGCIIFFSLAFIAACSSGLVFSRVTTNPVDLWSAPGSQARLEKEYFDAHFGPFFRTEQLIIQAPHTSVHTYQPYPSGSDVPFGPPLDIGILHQVLDLQTAIENITATYNNETVTLQDICVAPLSPYNKNCTIMSVLNYFQNSHSMLDHKIGDDFYVYADYHTHLLYCVRAPASLNDTSLLHDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFINFVKNYENPNLTISFTTERSIEDELNRESNGDVFTVLISYAVMFLYISIALGHIKSCSRFLVDSKISLGIAGILIVLSSVMCSLGIFSYFGIPLTLIVIEVIPFLVLAVGVDNIFILVQTYQRDERLQGETLEQQLGRVLGEVAPSMFLSSFSEAVAFFLGALSQMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLDLKRQEKNRLDVLCCLTGSEGGTGIQASESCLFRFFKNSYSPFLLKDWMRPIVIAVFVGILSFSIAVLNKVEIGLDQSLSMPDDSYMMDYFKSLKYLHAGPPVYFVLEEGHDYTSLEGQNMVCGGMGCNNDSLVQQIFSAAQLDNYTHIGFAPSSWIDDYFDWVKPQSSCCRVYNSTDQFCNASVVDPACVRCRPLTQEGKRRPQGEDFMRFLPMFLSDNPNPKCGKGGHAAYGSAVNLVGNDTSVGATYFMTYHTVLQTSADFTDAMRKAILIASNITKTMSLKGSHYRVFPYSVFYVFYEQYLTIIDDTIFNLSVSLGAIFLVTLVLLGCELWSAVIMCVTIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSAKGSRVERAEEALSHMGSSVFSGITLTKFGGIVVLAFAKSQIFQVFITGMYLAMVLLGATHGLIFLPVLLSYIGPSINKAKSLASQERYKGTEREQLLNF. |
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For Research Use Only | Not For Clinical Use.
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