Mouse Anti-E. coli cpxR (NDNGSPTLEVDA) Antibody

Cat: MOXC-007W
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  • Product Details


Host speciesMouse
Species ReactivityE. coli
ImmunogenE. coli cpxR (NDNGSPTLEVDA)
Buffer0.05 M Tris-HCl, pH 7.4, 100 mM glycine
Regulatory StatusFor Research Use Only
ShippingGel Pack
StorageStore at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles.
Purity> 90% was determined by SDS-PAGE
PurificationProtein A or G

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.


IntroductionResponse regulator member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA (PubMed:7883164, PubMed:9401031). Required for efficient binding of stationary phase cells to hydrophobic surfaces, part of the process of biofilm formation (PubMed:11830644). Induced upon cell surface binding, subsequently induces genes it controls (cpxP, dsbA and spy, degP is only partially induced) (PubMed:11830644). Binds and activates transcription from the degP promoter (PubMed:7883164); binding is enhanced by phosphorylation (PubMed:9401031). This system combats a variety of extracytoplasmic protein-mediated toxicities by increasing the transcription of the periplasmic protease, DegP in concert with sigma factor E (PubMed:7883164), as well as that of CpxP protein. Other downstream effectors may include SrkA (PubMed:23416055).
Product OverviewThis product is a Mouse antibody against the cpxR. It can be used for cpxR antibody detection in ELISA, but Western Blot can be tested by the end of the user.
Alternative NamesTranscriptional regulatory protein CpxR; cpxR; yiiA; b3912 JW3883
UniProt IDP0AE88


For Research Use Only | Not For Clinical Use.

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