Cat: MOXC-007W
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- Product Details
Specifications
| Host species | Mouse |
| Species Reactivity | E. coli |
| Clone | XM07 |
| Immunogen | E. coli cpxR (NDNGSPTLEVDA) |
| Epitope | NDNGSPTLEVDA |
| Format | Liquid |
| Buffer | 0.05 M Tris-HCl, pH 7.4, 100 mM glycine |
| Regulatory Status | For Research Use Only |
| Shipping | Gel Pack |
| Storage | Store at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles. |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Protein A or G |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | Response regulator member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA (PubMed:7883164, PubMed:9401031). Required for efficient binding of stationary phase cells to hydrophobic surfaces, part of the process of biofilm formation (PubMed:11830644). Induced upon cell surface binding, subsequently induces genes it controls (cpxP, dsbA and spy, degP is only partially induced) (PubMed:11830644). Binds and activates transcription from the degP promoter (PubMed:7883164); binding is enhanced by phosphorylation (PubMed:9401031). This system combats a variety of extracytoplasmic protein-mediated toxicities by increasing the transcription of the periplasmic protease, DegP in concert with sigma factor E (PubMed:7883164), as well as that of CpxP protein. Other downstream effectors may include SrkA (PubMed:23416055). |
| Product Overview | This product is a Mouse antibody against the cpxR. It can be used for cpxR antibody detection in ELISA, but Western Blot can be tested by the end of the user. |
| Alternative Names | Transcriptional regulatory protein CpxR; cpxR; yiiA; b3912 JW3883 |
| UniProt ID | P0AE88 |
Reference
See other products for " cpxR "
For Research Use Only | Not For Clinical Use.