Anti-FBRL Antibody (Cat MO-MMB-0549), Mouse IgG

Cat: MO-MMB-0549
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Host speciesMouse (Mus musculus)
Species ReactivityC. elegans (Caenorhabditis elegans), Fruit fly (Drosophila melanogaster), Human (Homo sapiens), Rat (Rattus norvegicus), Yeast
SpecificityThis clone was chosen because it is specific to ~34 kDa Fibrillarin.
ImmunogenHybridomas were screened by immunofluorescence on yeast cells and by western blotting on yeast protein homogenates (S. cerevisiae).
Regulatory StatusFor Research Use Only
ShippingGel Pack
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PurityConcentrated cell culture supernatant.

Application Information

ApplicationICC, WB
Application NotesWB: 1:1000-1:10000
ICC: 1:1000-1:5000
The optimal dilution should be determined by the end user.


IntroductionFibrillin is part of the small subunit processing complex and is involved in the processing of pre-18S ribosomal RNA. Nop1p is a yeast homolog of fibrillin. Fibrillarin/Nop1p is unusually conserved, so yeast and human proteins are 67% identical, and human proteins can functionally replace yeast proteins. This means that an appropriate cross-reactive antibody against Nop1p/fibrillarin (such as this antibody) can be used to reveal nucleoli and study fibrillarin/Nop1p in all eukaryotes and archaea tested so far. This antibody is being widely used as a convenient marker for nucleoli in many species.
Product OverviewThis product is a mouse antibody against the FBRL. It can be used for FBRL detection in Immunocytochemistry, Western Blot.
Alternative NamesrRNA 2'-O-methyltransferase fibrillarin; 34 kDa nucleolar scleroderma antigen; FBL; FIB1; FLRN; Nop1p
UniProt IDP15646


For Research Use Only | Not For Clinical Use.

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