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Anti-FBRL Antibody (Cat MO-MMB-0549), Mouse IgG


Cat: MO-MMB-0549
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityC. elegans (Caenorhabditis elegans), Fruit fly (Drosophila melanogaster), Human (Homo sapiens), Rat (Rattus norvegicus), Yeast
CloneM38F3
SpecificityThis clone was chosen because it is specific to ~34 kDa Fibrillarin.
ImmunogenHybridomas were screened by immunofluorescence on yeast cells and by western blotting on yeast protein homogenates (S. cerevisiae).
FormatLyophilized
Regulatory StatusFor Research Use Only
ShippingGel Pack
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PurityConcentrated cell culture supernatant.

Application Information

ApplicationICC, WB
Application NotesWB: 1:1000-1:10000
ICC: 1:1000-1:5000
The optimal dilution should be determined by the end user.

Target

IntroductionFibrillin is part of the small subunit processing complex and is involved in the processing of pre-18S ribosomal RNA. Nop1p is a yeast homolog of fibrillin. Fibrillarin/Nop1p is unusually conserved, so yeast and human proteins are 67% identical, and human proteins can functionally replace yeast proteins. This means that an appropriate cross-reactive antibody against Nop1p/fibrillarin (such as this antibody) can be used to reveal nucleoli and study fibrillarin/Nop1p in all eukaryotes and archaea tested so far. This antibody is being widely used as a convenient marker for nucleoli in many species.
Product OverviewThis product is a mouse antibody against the FBRL. It can be used for FBRL detection in Immunocytochemistry, Western Blot.
Alternative NamesrRNA 2'-O-methyltransferase fibrillarin; 34 kDa nucleolar scleroderma antigen; FBL; FIB1; FLRN; Nop1p
UniProt IDP15646
For Research Use Only | Not For Clinical Use.

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