Mouse Anti-Hsp60 Antibody (MOFAB-114W)


Cat: MOFAB-114W
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Specifications

Host speciesMouse
Species ReactivityHuman, Mouse, Rat, Rabbit, Bovine, Danine, Porcine, Ovine, Guinea Pig, Hamster, Chicken, Monkey, Xenopus, Drosophila
CloneWLK
SpecificityThis antibody recognizes human, mouse, rat, rabbit, bovine, canine, porcine, sheep, guinea pig, hamster, chicken, monkey, Xenopus and Drosophila Hsp60 (60 kDa). It does not cross-react with bacterial or yeast Hsp60. The recognized epitope is within aa 383-447 of human Hsp60.
ImmunogenRecombinant human Hsp60 expressed in E. coli.
FormatLiquid or Lyophilized
BufferPBS, pH 7.4, 50% glycerol
Regulatory StatusFor Research Use Only
ShippingGel Pack
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
PurificationProtein G

Application Information

ApplicationWB, IP, FC
Application NotesIB: 0.1-1ug/ml
IP: 12.5ug/ml
FC: 10ug/ml
The optimal dilution should be determined by the end user.

Target

IntroductionHsp60 is an abundant protein that is constitutively synthesized in various cell types and is induced to higher concentrations after cellular shock. It is present in the mitochondria of many mammalian species and has highly similar counterparts in bacteria and plants (it is localized to the chloroplast). In general, Hsp60 proteins are present in high concentrations, are induced in response to environmental stress (such as heat shock), are homo-oligomeric structures of 7 or 14 subunits, dissociate reversibly in the presence of Mg2+ and ATP, have ATP Enzymatic activity, and plays a role in the folding and assembly of oligomeric protein structures. Hsp60 has been implicated in Alzheimer's disease, coronary artery disease, multiple sclerosis, diabetes and other autoimmune diseases.
Product OverviewThe Hsp60 antibody is used as Heat Shock and Stress Protein Antibodies.
Alternative NamesProtein HSP-60, isoform b; hsp-60; Hsp60
For Research Use Only | Not For Clinical Use.
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