Mouse Anti-IGHM Antibody (CBMOAB-45147FYA)

Cat: CBMOAB-45147FYA

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Lot Number

Product List
Specifications
Application Information
Target

Sub Cat	Clonality	Species Reactivity	Application	Clone	Conjugate	Size
CBMOAB-45147FYA	Monoclonal	Rhesus (Macaca mulatta), Pig (Sus scrofa), Zebrafish (Danio rerio)	WB, ELISA	MO45147FYA		100 µg	Inquiry
Protein Refseq: The length of the protein is 614 amino acids long. The sequence is show below: MEFRLSWVFLVAVLKGVQCEVQLVESGGGLVQPGGSLRLSCTGSGFTFSSYYMYWVRQAPGKGLEWVSAINTGGGSTWYTDSVKGRFTISKENAKNTLYLQMDSLRAEDTAVYYCAKDTQQGLSTLPFWGQGALVTVSSGESAGPFKWEPSVSSPNAPLDTNEVAVVCLAQDFLPDSITFSWKFKNNSDISKGVWGFPSVLRGGKYAATSQVLLASKDVMQGTDEHVVCKVQHPNGNKEQNVPLPVLAERPPNVSVFVPPRDGFVGNPRESKLICQATGFSPRQIEVSWLREGKQVGSGITTDRVEAEAKESGPTTFKVTSTLTVSERDWLSQSVFTCRVDHRGLTFQKNVSSVCGPNPDTAIRVFAIPPSFASIFLTKSTKLTCLVTDLATYDRVTITWTRQNGEALKTHTNISESHPNGTFSAVGEASICEDDWNSGERFRCTVTHTDLPSPLKQTISRPKGVAMHRPDVYLLPPAREQLNLRESATITCLVTGFSPADIFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEDWNTGETYTCVVAHEALPNRVTERTVDKSTGKPTLYNVSLVILWTTLSTFVALFVLTLLYSGIVTFIKVR.
CBMOAB-80440FYA	Monoclonal	Zebrafish (Danio rerio)	WB, ELISA	MO80440FYA		100 µg	Inquiry
Protein Refseq: The length of the protein is 570 amino acids long. The sequence is show below: MDVLQFGVLLMIVSTVRGQSLTSSDSVVKRPGESVTLSCTVSGISMSRYWMHWIRQKPGKGLEWIGYIDTGTTAYYAQSLQGQFTITKDTSKNMLYLEVKSLKSEDTAVYYCARTAYYFDYWGKGTKVTVSSAQPSAPQSVFGLSQCSSGSDGSITLGCLAKGFSPADSLNFKWKDPAGKDLSDFVQYPAFGKEGDYTKISHIRVRKSDWDAKKPYTCEASNSVGAPKTASLAPPAPPPDLRATVFLTAPTKMELEGGSATFMCLARRFSPKQYEFKWYQNDQEVTNAVDNFFKDEKNGSVTEYSATSILKINAETWKQAESKVKCVFEHNKRNDSREIQYKDTMQDCIDDNVHIDIIPPTPEDMLKNRKGILKCKASGNPQFHFTKIEIKANDLVIAEKEEPLTNREELDAPINYQEWSNGTVFKCIAENTGKTLPEEKTFVRENGKKRPSVYVLAPPENKANEAMTLTCYVKNFLPKEVFVTWLVNDEPAYGYKNSTSEPVENDDSFSMYSQITVENSEWTGGKVYTCVVYHESIDEKLLVLTRSITDNMDKSSIINLSMTTPAPCKA.
MO-AB-26612R	Monoclonal	Pig (Sus scrofa)	WB, ELISA	MO26612R		100 µg	Inquiry
Protein Refseq: The length of the protein is 455 amino acids long. The sequence is show below: SQSAPNLFPLVSCVSPPSDESLVALGCLARDFLPSSVTFSWNYKNSSKVSSQNIQDFPSVLRGGKYLASSRVLLPSVSIPQDPEAFLVCEVQHPSGTKSVSISGPVVEEQPPVLNIFVPTRESFSSTPQRTSKLICQASDFSPKQISMAWFRDGKRVVSGVSTGPVETLQSSPVTYRLHSMLTVTESEWLSQSVFTCQVEHKGLNYEKNASSLCTSNPNSPITVFAIAPSFAGIFLTKSAKLSCLVTGLVTRESLNISWTRQDGEVLKTSIVFSEIYANGTFGARGEASVCVEDWESGDRFTCTVTHTDLPSPLKQSVSKPRGIARHMPSVYVLPPAPEELSLQEWASVTCLVKGFSPADVFVQWLQKGEPVSADKYVTSAPVPEPEPKAPASYFVQSVLTVSAKDWSDGETYTCVVGHEALPHTVTERTVDKSTGKPTLYNVSLVLSDTASTCY.

Specifications

Host species	Mouse (Mus musculus)
Species Reactivity	Rhesus (Macaca mulatta), Pig (Sus scrofa), Zebrafish (Danio rerio)
Clone	MO45147FYA
Specificity	This antibody binds to Rhesus IGHM.
Format	Liquid or Lyophilized
Storage	Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use
Purity	> 90% was determined by SDS-PAGE
Purification	Purified with Protein A or G affinity chromatography

Application Information

Application	WB, ELISA
Application Notes	ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

Introduction	Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).
Product Overview	Mouse Anti-Rhesus IGHM Antibody is a mouse antibody against IGHM. It can be used for IGHM detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative Names	IGHM
UniProt ID	F6W3M2
Protein Refseq	The length of the protein is 614 amino acids long. The sequence is show below: MEFRLSWVFLVAVLKGVQCEVQLVESGGGLVQPGGSLRLSCTGSGFTFSSYYMYWVRQAPGKGLEWVSAINTGGGSTWYTDSVKGRFTISKENAKNTLYLQMDSLRAEDTAVYYCAKDTQQGLSTLPFWGQGALVTVSSGESAGPFKWEPSVSSPNAPLDTNEVAVVCLAQDFLPDSITFSWKFKNNSDISKGVWGFPSVLRGGKYAATSQVLLASKDVMQGTDEHVVCKVQHPNGNKEQNVPLPVLAERPPNVSVFVPPRDGFVGNPRESKLICQATGFSPRQIEVSWLREGKQVGSGITTDRVEAEAKESGPTTFKVTSTLTVSERDWLSQSVFTCRVDHRGLTFQKNVSSVCGPNPDTAIRVFAIPPSFASIFLTKSTKLTCLVTDLATYDRVTITWTRQNGEALKTHTNISESHPNGTFSAVGEASICEDDWNSGERFRCTVTHTDLPSPLKQTISRPKGVAMHRPDVYLLPPAREQLNLRESATITCLVTGFSPADIFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEDWNTGETYTCVVAHEALPNRVTERTVDKSTGKPTLYNVSLVILWTTLSTFVALFVLTLLYSGIVTFIKVR.

For Research Use Only | Not For Clinical Use.

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