Mouse Anti-IL-17A Antibody (MOFAB-340W)


Cat: MOFAB-340W
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Specifications

Host speciesMouse
Species ReactivityCow, Goat, Sheep
CloneWMT51B8
SpecificityNatural and recombinant IL-17A from bovine. Cross-reacts with IL-17A in sheep and goats.
FormatLiquid
BufferPBS
Regulatory StatusFor Research Use Only
ShippingGel Pack
StorageStore at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles.

Application Information

ApplicationELISA, ELISpot
Application NotesThe optimal dilution should be determined by the end user.

Target

IntroductionIL-17A (IL-17A, IL17A) is a potent pro-inflammatory cytokine produced by activated Th17 (T helper 17) cells and certain cells belonging to the innate immune system. In mice, IL-17 has also been shown to be produced by activated CD8+ T cells and γδ T cells. Th17 cells play an important role in autoimmune diseases and resistance to bacteria and fungi. IL-17A acts on a wide range of cell types to induce the expression of cytokines, chemokines and metalloproteinases. Therefore, secretion of IL-17A promotes the inflammatory response, which leads to the recruitment of neutrophils, enhancement of antibody production, and activation of T cells. Increased IL-17A expression is seen in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. It has also been linked to asthma, psoriasis, cancer and transplant rejection.
Product OverviewThe IL-17A antibody is used as Veterinary research antibodies.
Alternative NamesInterleukin-17A/F-1; IL-17A/F-1; bovine IL-17A
For Research Use Only | Not For Clinical Use.

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