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Rat Anti-ITGAM Antibody (MOFY-0522-FY47)


Cat: MOFY-0522-FY47
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Specifications

Host speciesRat
Species ReactivityMouse, Human, Rhesus, Baboon, Rabbit
ImmunogenC57BL/10 mouse spleen T cells and concanavalin A-activated C57BL/10 spleen cells
FormatLiquid
BufferPBS
Regulatory StatusFor Research Use Only. Not For Clinical Use.
ShippingGel Pack
StorageStore at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles.

Application Information

ApplicationFC
Application NotesThe optimal dilution should be determined by the end user.

Target

IntroductionIntegrin αM (ITGAM) is a protein subunit that can form heterodimeric integrin α-Mbeta-2 (αMβ2) molecules, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). ITGAM, also known as CR3A, is a cluster of differentiation molecules 11B (CD11B). The second chain of αMβ2 is a common integrin β2 subunit called CD18, so integrin αMβ2 belongs to the β2 subfamily (or leukocyte) integrin.

αMβ2 is expressed on the surface of many white blood cells involved in the innate immune system, including monocytes, granulocytes, macrophages and natural killer cells. It mediates inflammation by regulating the adhesion and migration of leukocytes, and is related to various immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cell activation. It participates in the complement system because it has the ability to bind the inactivated complement component 3b (iC3b). The ITGAMα subunit of integrin αMβ2 is directly involved in causing cell adhesion and spreading, but if β2 (CD18) subunit is not present, it cannot mediate cell migration.
Product OverviewRat Anti-ITGAM Antibody (MOF032922W215) is a Rat antibody against ITGAM. It can be used for ITGAM detection in Flow Cytometry.
Alternative NamesITGAM; CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6; integrin subunit alpha M
Gene ID714832(Rhesus)
For Research Use Only | Not For Clinical Use.

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