Rabbit Anti-lexA Antibody (MO-DKB-00177W)
Cat: MO-DKB-00177W
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- Product Details
Specifications
Host species | Rabbit (Oryctolagus cuniculus) |
Species Reactivity | E. coli (Escherichia coli) |
Specificity | This antibody is binds to Escherichia coli lexA. |
Immunogen | Recombinant Escherichia coli LexA Repressor Protein |
Epitope | The epitope is in the AA 1-202 of lexA. |
Format | Liquid or Lyophilized |
Buffer | PBS pH 7.4, 50% Glycerol |
Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
Purity | > 95% was determined by SDS-PAEG |
Purification | Purified with G affinity chromatography |
Application Information
Application | ELISA |
Target
Introduction | Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment (PubMed:20005847).The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in response to DNA damaging agents that is mediated by RecA and LexA (PubMed:22412352). |
Product Overview | This product is a rabbit antibody against the AA 1-202 of the lexA. It can be used for lexA detection in Enzyme-Linked Immunosorbent Assay. |
Alternative Names | LexA repressor; EC 3.4.21.88; lexA; exrA spr tsl umuA; b4043 JW4003 |
UniProt ID | P0A7C2 |
See other products for " lexA "
CBMOAB-1491YC | Mouse Anti-E. coli lexA Antibody (CBMOAB-1491YC) |
MO-MMB-0711 | Anti-LexA Antibody (Cat MO-MMB-0711), Rabbit IgG |
For Research Use Only | Not For Clinical Use.
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