Mouse Anti-Medaka itr1 Antibody (MO-AB-00778R)
Cat: MO-AB-00778R
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- Product Details
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | Medaka (Oryzias latipes) |
| Clone | MO00778R |
| Specificity | This antibody binds to Medaka itr1. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis (PubMed:10499793, PubMed:10610772, PubMed:15194811, PubMed:16186564, PubMed:23671426). Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position (PubMed:10610772). Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity (PubMed:10610772). Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyngeal pumping (PubMed:10499793, PubMed:11553721, PubMed:12062062, PubMed:11950942, PubMed:15013747, PubMed:15133127, PubMed:16186564, PubMed:21191812). Affects normal hermaphrodite and male fertility as a participant in intracellular signaling by acting downstream of let-23/lin-3 which regulates ovulation, spermathecal valve dilation and male mating behavior (PubMed:9491893, PubMed:15194811, PubMed:16267094, PubMed:15958491). Important for early embryonic development; controls epidermal cell migration and may also regulate filopodial protrusive activity during epithelial morphogenesis (PubMed:11950942, PubMed:15498499, PubMed:18369461). Component of inositol trisphosphate (IP3)-mediated downstream signaling pathways that controls amphid sensory neuronal (ASH)-mediated response to nose touch and benzaldehyde but not other ASH-mediated responses (PubMed:19730689). |
| Product Overview | This product is a mouse antibody against itr1. It can be used for itr1 detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Isotocin receptor 1; itr1 |
| UniProt ID | H1ADE8 |
| Protein Refseq | The length of the protein is 384 amino acids long. The sequence is show below: MEDLLLELESWSHNVSARNSSCRNESGAENSTVNPLKRNEEAAKVEVTVLVLVLFLALMGNLCVLLAIHTTKHSHSRMYYFMKHLSIADLVVAVFQVLPQLIWDITFRFYGPDILCRLVKYLQVVGMFASTYMLVLMSVDRCSAICLPFRFVNKRRDRICVIASWMLSLVFSAPQAYIFSLKEVGNGVYDCWGDFVHPWGAKAYITWMSLSIYILPVAILGICYGLICFKIWENINMKTRRDRFVAVTSKGTHPLSRVSSVRLISKAKIRTVKMTFVVVIAYIVCWTPFFFVQMWSAWDPAAPREDMAFIIAMLLASLNSCCNPWIYMFFAGHLFHDLIQCFFSCCRQYLTDSSCGCDEQRRDKSSSSSDVIKNAREASHTHPA. |
See other products for " ITR1 "
| CBMOAB-05494HCB | Mouse Anti-C. elegans ITR1 Antibody (CBMOAB-05494HCB) |
| CBMOAB-00038CR | Mouse Anti-Yeast ITR1 Antibody (CBMOAB-00038CR) |
For Research Use Only | Not For Clinical Use.
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