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Rabbit Anti-Mouse GPX4 Antibody (CBMOAB-00314FYA)


Cat: CBMOAB-00314FYA
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Specifications

Host speciesRabbit (Oryctolagus cuniculus)
Species ReactivityHuman (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Zebrafish (Danio rerio)
CloneF00314FYA
SpecificityThis antibody is binds to Mouse GPX4 and has cross reactivity with Human, Rat, Zebrafish.
FormatLiquid
BufferTBS, pH 7.4
PurificationPurified with Protein A affinity chromatography
Cellular LocalizationMitochondrion

Application Information

ApplicationWB, IHC
Application NotesWB: 1:500-1:2,000
IHC: 1:50-1:200

Target

IntroductionThe protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.
Product OverviewRabbit Anti-Mouse GPX4 (clone F00314FYA) Antibody (CBMOAB-00314FYA) is a Rabbit antibody against the GPX4. It can be used for GPX4 detection in Western Blot, Immunohistochemistry.
Alternative NamesGlutathione Peroxidase 4; Phospholipid Hydroperoxidase; EC 1.11.1.12; GSHPx-4; GPx-4; PHGPx; Phospholipid Hydroperoxide Glutathione Peroxidase, Mitochondrial; Glutathione Peroxidase 4 (Phospholipid Hydroperoxidase)
Gene ID2879
UniProt IDP36969
For Research Use Only | Not For Clinical Use.

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