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Rabbit Anti-Mouse JNK1 / JNK2 / JNK3 Antibody (CBMOAB-00266FYA)


Cat: CBMOAB-00266FYA
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Specifications

Host speciesRabbit (Oryctolagus cuniculus)
Species ReactivityHuman (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Cattle (Bos taurus), Monkey (Macaca mulatta), Zebrafish (Danio rerio)
CloneF00266FYA
SpecificityThis antibody is binds to Mouse JNK1 / JNK2 / JNK3 and has cross reactivity with Human, Rat, Cattle, Monkey, Zebrafish.
FormatLiquid
BufferTBS, pH 7.4
PurificationPurified with Protein A affinity chromatography
Cellular LocalizationCytoplasm; Nucleus; Membrane; Mitochondrion

Application Information

ApplicationWB, IF, IP
Application NotesWB: 1:1,000-1:5,000
ICC: 1:50-1:200

Target

IntroductionThe protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
Product OverviewRabbit Anti-Mouse JNK1 / JNK2 / JNK3 (clone F00266FYA) Antibody (CBMOAB-00266FYA) is a Rabbit antibody against the JNK1 / JNK2 / JNK3. It can be used for JNK1 / JNK2 / JNK3 detection in Western Blot, Immunofluorescence, Immunoprecipitation.
Alternative NamesMitogen-Activated Protein Kinase 8; Stress-Activated Protein Kinase 1c; C-Jun N-Terminal Kinase 1; JUN N-Terminal Kinase; MAP Kinase 8; EC 2.7.11.24; JNK-46; SAPK1c; PRKM8; SAPK1; JNK1
Gene ID5599
UniProt IDP45983
For Research Use Only | Not For Clinical Use.

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