Rabbit Anti-NR3C1 (AA 1-150, clone ms2109-026) Antibody (Cat MO-DKB-03618W)


Cat: MO-DKB-03618W
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Specifications

Host speciesRabbit (Oryctolagus cuniculus)
Species ReactivityHuman (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Zebrafish (Danio rerio)
Clonems2109-026
SpecificityThis antibody is binds to Human Glucocorticoid Receptor and has cross reactivity with Mouse, Rat, Zebrafish Glucocorticoid Receptor.
ImmunogenHuman glucocorticoid receptor between 1 and 150 amino acids
EpitopeAA 1-150
FormatLiquid
BufferTBS, pH 7.4, 1% BSA, 40% Glycerol
StorageStore at -20 °C for 12 months.
PurificationProtein A purified

Application Information

ApplicationWB, FC
Application NotesWestern Blot: 1:300-1000
Flow Cytometry: 1:20-100
The optimal dilution should be determined by the end user.

Target

IntroductionThis gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
Product OverviewThis product is a Rabbit antibody against the Glucocorticoid Receptor. It can be used for Glucocorticoid Receptor detection in Western Blot, Flow Cytometry.
Alternative NamesGlucocorticoid receptor beta; nr3c; Glucocorticoid receptor; Nuclear receptor subfamily 3 group C member 1; GR; NR3C1
UniProt IDB1NAT5
For Research Use Only | Not For Clinical Use.

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