Rabbit Anti-NR3C1 Antibody


Cat: MO-NAB-00478W
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Specifications

Host speciesRabbit (Oryctolagus cuniculus)
Species ReactivityHuman (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Zebrafish (Danio rerio)
CloneNW0400
SpecificityThis antibody is binds to Human NR3C1 and has cross reactivity with Mouse, Rat, Zebrafish.
FormatLiquid
BufferTBS, pH7.4, 1% BSA, 40% Glycerol.
StorageStore at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PurificationProtein A purified

Application Information

ApplicationWB, FC
Application NotesWestern Blot: 1:1000-1:5000
Flow Cytometry: 1:50-1:100

Target

IntroductionThis gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
Product OverviewThis product is a Rabbit antibody against the NR3C1. It can be used for NR3C1 detection in Western Blot, Flow Cytometry.
Alternative NamesNuclear Receptor Subfamily 3 Group C Member 1; Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor); Glucocorticoid Receptor; GRL; GR; Nuclear Receptor Subfamily 3, Group C, Member 1
Gene ID2908(Human); 14815(Mouse); 24413(Rat)
UniProt IDP04150(Human); P06537(Mouse); P06536(Rat)
For Research Use Only | Not For Clinical Use.

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