Mouse Anti-Rabbit MMP2 Antibody (MO-AB-08843Y)


Cat: MO-AB-08843Y
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityRabbit (Oryctolagus cuniculus)
CloneMO08843Y
SpecificityThis antibody binds to Rabbit MMP2.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationExtracellular region or secreted; Other locations; Nucleus

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionUbiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues (By similarity).
Product OverviewThis product is a mouse antibody against MMP2. It can be used for MMP2 detection in Western Blot and Enzyme-Linked Immunosorbent Assay.
Alternative Names72 kDa type IV collagenase; EC 3.4.24.24; 72 kDa gelatinase; Gelatinase A; Matrix metalloproteinase-2; MMP-2; [Cleaved into: PEX]; MMP2
UniProt IDP50757
Protein RefseqThe length of the protein is 662 amino acids long. The sequence is show below: MEALGARGALAGFLRALCVLGCLLGRATAPPSPVIKFPGDVAPKTDKELAVQYLNTFYGCPKDSCNLFVLKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSNVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYTSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYSSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTIGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATSTNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDAGTDAGTGPTPTLGPVTPEICTQDIVFDGIAQIRGEIFFFKDRFIWRTVTPGDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPRLIADAWNAIPDHLDAVVDLQGSGHSYFFKGTYYLKLENQSLKSVKVGSIKTDWLGC.
For Research Use Only | Not For Clinical Use.
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