Mouse Anti-Rabbit NR3C1 Antibody (MO-AB-08997Y)
Cat: MO-AB-08997Y
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- Product Details
Specifications
Host species | Mouse (Mus musculus) |
Species Reactivity | Rabbit (Oryctolagus cuniculus) |
Clone | MO08997Y |
Specificity | This antibody binds to Rabbit NR3C1. |
Format | Liquid or Lyophilized |
Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
Purity | > 90% was determined by SDS-PAGE |
Purification | Purified with Protein A or G affinity chromatography |
Cellular Localization | Nucleus; Other locations; Mitochondrion; Cytoskeleton |
Application Information
Application | WB, ELISA |
Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
Introduction | Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Mediates glucocorticoid-induced apoptosis. Promotes accurate chromosome segregation during mitosis. May act as a tumor suppressor. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression. |
Product Overview | This product is a mouse antibody against NR3C1. It can be used for NR3C1 detection in Western Blot and Enzyme-Linked Immunosorbent Assay. |
Alternative Names | Glucocorticoid receptor; GR; Nuclear receptor subfamily 3 group C member 1; NR3C1; GRL |
UniProt ID | P59667 |
Protein Refseq | The length of the protein is 772 amino acids long. The sequence is show below: MDSKESLSPPGREEVPSSVLRPAERGNVMDLYKTLRGGAPVRVPASSPSLAPAAQPDSKQQRLAVDFPKGSASNAQQPDLSRAVSLSMGLYMGETETKVMGSDLAFPQQGQTSLSSGETDFRLLEESIASLNRSASGADNPRSTAPAAGSAAPTEGFPKTHSDLASERQNPKGQTGGSAGSAKLHPTDQSTFDILQDLEFSGSPSKDRSESPWRSDLLMDENCLLSPLAGEDDPFLLEGNSSEDCKPLILPDTKPKIKDNGDLILSNSNNVPLPQVKTEKEDFIELCTPGVIKQEKLGPVYCQASFSGANIIGNKISAISVHGVSTSGGQMYHYDMNAQQQEQKPLFNVIPPIPVGSENWNRCQGSGDDNLTSLGTMNFPGRSVFSNGYSSPGMRPDVSSPPSNSTTAAGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVKGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQTSTGVSQETSENPSNRTVVPAALPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYKQSSGNMLCFAPDLVINEQRMTLPYMYDQCKHMLFVSSELKRLQVSYEEYLCMKTLLLLSTVPKEGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLHYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK. |
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For Research Use Only | Not For Clinical Use.
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