Mouse Anti-Rat Fadd Antibody (MO-AB-25715H)
Cat: MO-AB-25715H
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- Product Details
Specifications
Host species | Mouse (Mus musculus) |
Species Reactivity | Rat (Rattus norvegicus) |
Clone | MO25715C |
Specificity | This antibody binds to Rat Fadd. |
Format | Liquid or Lyophilized |
Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
Purity | > 90% was determined by SDS-PAGE |
Purification | Purified with Protein A or G affinity chromatography |
Cellular Localization | Plasma membrane; Cytosol; Nucleus; Other locations |
Application Information
Application | WB, ELISA |
Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
Introduction | The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. |
Product Overview | This product is a mouse antibody against Fadd. It can be used for Fadd detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
Alternative Names | FADD/MORT1 protein with death effector domain; Fas death domain associated protein; Protein Fadd; Fas (TNFRSF6)-associated via death domain; Fadd; fadd |
UniProt ID | Q8R2E7 |
Protein Refseq | The length of the protein is 208 amino acids long. The sequence is show below: MDPFLVLLHSLSSSLSGNDLTDLKFLCRERVSKRKLERVQSGLDLFSVLLEQNDLERGHTGLLRELLASLGRHDLLQRLDDFEAGATTAATPGEADLRVAFDIVCDNVGRDWKRLARELKVSEAKIDGIEERYPRSLSDRVRETLRVWKNVEKENASVAGLVKALRACRLNLVADLVEEALMAQGSVSKSDDTSSALRDSTVSFSETP. |
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For Research Use Only | Not For Clinical Use.
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