Cat: CBMOAB-34735FYA
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- Product Details
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | Rhesus (Macaca mulatta) |
| Clone | MO34735FYA |
| Specificity | This antibody binds to Rhesus A2M. |
| Format | Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
| Cellular Localization | Extracellular region or secreted |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. |
| Product Overview | Mouse Anti-Rhesus A2M (clone MO34735FYA) Antibody (CBMOAB-34735FYA) is a mouse antibody against A2M. It can be used for A2M detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | A2M |
| UniProt ID | F6TNV9 |
| Protein Refseq | The length of the protein is 1474 amino acids long. The sequence is show below: MGRNTLLHPSLVLLLLVLLPTDVSVSGKPQYMVLVPSLLHTETPEKGCVLLSYLNETVTVSASLESVRGNRSLFTDLEAENDVLHCVAFAVPKSSSNEEVMFLTVQVKGPTQEFKKRTTVMVKNEESLVFVQTDKSIYKPEQTVKFRVVSLDENFHPVNELIPLVYIQDPKGNRIAQWQSFQLEGGLKQLSFPLSSEPFQGSYKVVVQKKSGRRTEHPFTVEEFVLPKFEVQVTVPKIITILEEEMNVSVCGLYTYGKPVPGHVTVSICRKYSDASDCFGEDSKAFCEKFSGQLNSHGCFYQQVKTKVFQLKRKEYEMKLHTEAKIQEEGTVVELTGKKSSEITRTITKLSFVKVDSHFRQGIPFFGQVRLVDGKGVPIPNKVIFIRGNEANYYSNATTDEHGLVQFSINTTNVMGTTLTVRVKHKDRSPCYGYQWVSEEHEEAHHTAYLVFSPSKSFVHLEPLPHELPCGQTQTVQAHYILNGGALQGLKKLSFYYLIMARGGIVRTGTHGLLVKQEHMKGHFSISIPVKSDIAPVARLLIYAVLPTGDVIGDSAKYEVENCLDNKVDLSFRPSQSLPASHAHLQVTAAPQSLCALRAVDQSVLLMKPDAELSASSVYNLLPVKDLTGFPEPLNDQDDEDCVNRHNVYINGITYTPVSNTNEKDIYSFLQDMSLKAFTNSKIRKPKICPQLQQYEMHGPEGLRVGYYDSDVMGRGQARKLQLEEPHTETVRKYFPETWIWDLVVVNSSGVAEVGVTVPDTITDWKAGAFCLSQDSGLGISPTASLRAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPKCIRVSVQLEASPAFLAVPVEKEQEPHCICANGRQTVSWAITPKSLGNVNFTVSAEALESQELCGTEVASVPQYGKKDTIIKPLLVEPEGLEKETTFNSLLCPSGGEVSEELSLKLPPNVVEESARASVSVLGDILGSAMQNIQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLTPEIESKAIGYLNTGYQRQLNYKHYDGSYSTFGERYGRNQGNTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQKQKDNGCFRSSGSLLNNAIKGGVEDEVTLSAYITIALLEIPLPVTHPVVRNALFCLESAWKTTQEGAHGSHVYTKALLAYAFALAGNQEKRKEVLESLNEEAVKKDNSVHWERPQKPKAPVGHFYEPQAPSAEVEMTSYVLLAYLTAQPAPTSEDLTSATNVVKWITKQQNSQGGFSSTQDTVVALHALSKYGAATFTRTGKAAQVTIQSSGTFSNKFQVDNSNRLLLQRVSLPELPGEYSMKVTGEGCVYLQTSLKYNILPEKEEFPFALGVQTLPATCEEPKAHTSFQISLSVSYTGSRSASNMAIVDVKMVSGFIPLKPTVKTLERSNHVSRTEVSNNHVLIYLDKVSNQTLSLFFTVLQDVPVRDLKPAVVKVYDYYETDEFAIAEYNAPCSKDLGNA. |
See other products for " A2M "
For Research Use Only | Not For Clinical Use.