Mouse Anti-Rhesus APC2 Antibody (CBMOAB-35986FYA)


Cat: CBMOAB-35986FYA
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

  • Product Details

Specifications

Host speciesMouse (Mus musculus)
Species ReactivityRhesus (Macaca mulatta)
CloneMO35986FYA
SpecificityThis antibody binds to Rhesus APC2.
FormatLyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionThis gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. This gene also plays a role in actin assembly, cell-cell adhesion, and microtubule network formation through its interaction with cytoskeletal proteins. This gene has its highest expression in the central nervous system and is involved in brain development through cytoskeletal regulation in neurons. Alternative splicing produces multiple transcript variants encoding distinct isoforms.
Product OverviewMouse Anti-Rhesus APC2 (clone MO35986FYA) Antibody (CBMOAB-35986FYA) is a mouse antibody against APC2. It can be used for APC2 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesAdenomatous polyposis coli protein 2; APC2
UniProt IDH9F512
Protein RefseqThe length of the protein is 239 amino acids long.
The sequence is show below: RPGPGERPARRTSSESPSRLPVRAPAARPETVKRYASLPHISVARRPDGAVPAAPAPADAARRSSDGEPRSLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLESREPPGAPASGQLSLLGSDVDGPSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSARVPPFNYVPSPMVVAATTDSAAEKAPATSSATLLE.
For Research Use Only | Not For Clinical Use.

Online Inquiry