Cat: MO-AB-01321W
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- Product Details
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | Rhesus (Macaca mulatta) |
| Clone | MO01321W |
| Specificity | This antibody binds to Rhesus BRCA1. |
| Format | Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
| Cellular Localization | Nucleus |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. |
| Product Overview | Mouse Anti-Rhesus BRCA1 (clone MO01321W) Antibody (MO-AB-01321W) is a mouse antibody against BRCA1. It can be used for BRCA1 detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Breast cancer type 1 susceptibility protein isoform 3; BRCA1 |
| UniProt ID | H9FD01 |
| Protein Refseq | The length of the protein is 353 amino acids long. The sequence is show below: EIKKKNYNQMPVRHSRNLQLMEDKESATGAKKSNKPNEQTSKRHASDTFPELKLTKVPGSFTNCSNTSELKEFVNPSLSREEKEEKLETVKMSNNAKDPKDLMLSGERVLQTERSVESSSISLVPGTDYGTQESISLLEVSTLGKAKTERNKCMSQCAAFENPKELIHGCSEDTRNDTEGFKYPLGSEVNHSQETSIEIEESELDTQYLQNTFKVSKRQSFALFSNPGNPEEECATFSAHSRSLKKQSPKVTSECEQKEENQGKKESNIKPVQTVNITAGFSVVCQKDKPVDNAKCSIKGGSRFCLSSQFRGNETGLITPNKHGLLQNPYHIPPLFPVKSFVKTKCNKNLLEE. |
See other products for " BRCA1 "
| MO-AB-01319W | Mouse Anti-Rhesus BRCA1 Antibody (MO-AB-01319W) |
| CBMOAB-37083FYA | Mouse Anti-Rhesus BRCA1 Antibody (CBMOAB-37083FYA) |
| CBMOAB-37082FYA | Mouse Anti-Rhesus BRCA1 Antibody (CBMOAB-37082FYA) |
| MO-AB-15023W | Mouse Anti-Chimpanzee BRCA1 Antibody (MO-AB-15023W) |
| MO-AB-15022W | Mouse Anti-Chimpanzee BRCA1 Antibody (MO-AB-15022W) |
| MO-AB-15024W | Mouse Anti-Chimpanzee BRCA1 Antibody (MO-AB-15024W) |
| MO-AB-24182R | Mouse Anti-Pig BRCA1 Antibody (MO-AB-24182R) |
| MO-AB-29265W | Mouse Anti-Dog BRCA1 Antibody (MO-AB-29265W) |
| MO-AB-51933W | Mouse Anti-Marmoset BRCA1 Antibody (MO-AB-51933W) |
| MO-AB-01921H | Mouse Anti-Frog brca1 Antibody (MO-AB-01921H) |
For Research Use Only | Not For Clinical Use.