Mouse Anti-Rhesus MPL Antibody (CBMOAB-51625FYA)


Cat: CBMOAB-51625FYA
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Size:
Conjugate:
 Inquiry
  • Product Details

Specifications

Host speciesMouse (Mus musculus)
Species ReactivityRhesus (Macaca mulatta)
CloneMO51625FYA
SpecificityThis antibody binds to Rhesus MPL.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationPlasma Membrane; Nucleus; Golgi apparatus; Other locations

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionIn 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
Product OverviewMouse Anti-Rhesus MPL Antibody is a mouse antibody against MPL. It can be used for MPL detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesMPL
UniProt IDF7EPD2
Protein RefseqThe length of the protein is 625 amino acids long.
The sequence is show below: MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPGEKPRACPLSSQSVPRFGTRYVCQFPAQEEVRLFSPLHLWVKNVFLNQTQIQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEAPAPEISDFLRYELRYGPKDLKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPTREASALTAVGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVAIGLQCFTLDLKNVTCQWQQEDHARSQGFFYHSRARCCPRDRYPIWEDCEEEEKTNPGLQTPQFSRCHFKSRNDSVIHILVEVTTAVGAVHSSLGSPFWIHQGVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVWSSNKRPQTSLRRGSLGLAMPVSRSESVYVSIYLCLSDSTGILVSLEHPILLATLLNISLPFVFGISVLLIFSPRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQSQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP.
See other products for " MPL "
MO-AB-59266WMouse Anti-Marmoset MPL Antibody (MO-AB-59266W)
MO-AB-08858YMouse Anti-Rabbit MPL Antibody (MO-AB-08858Y)
CBMOAB-1732YCMouse Anti-E. coli mpl Antibody (CBMOAB-1732YC)
CBMOAB-87254FYAMouse Anti-Zebrafish mpl Antibody (CBMOAB-87254FYA)
MO-AB-27163HMouse Anti-Rat MPL Antibody (MO-AB-27163H)
MO-AB-42096WMouse Anti-Guinea pig MPL Antibody (MO-AB-42096W)
For Research Use Only | Not For Clinical Use.
Online Inquiry