Mouse Anti-Sheep CD4 Antibody (MO-AB-14502Y)
Cat: MO-AB-14502Y
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Size: | |
Conjugate: | |
Inquiry |
- Product Details
Specifications
Host species | Mouse (Mus musculus) |
Species Reactivity | Sheep (Ovis aries) |
Clone | MO14502Y |
Specificity | This antibody binds to Sheep CD4. |
Format | Liquid or Lyophilized |
Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
Purity | > 90% was determined by SDS-PAGE |
Purification | Purified with Protein A or G affinity chromatography |
Cellular Localization | Plasma membrane; Other locations |
Application Information
Application | WB, ELISA |
Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
Introduction | Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. |
Product Overview | This product is a mouse antibody against CD4. It can be used for CD4 detection in Western Blot and Enzyme-Linked Immunosorbent Assay. |
Alternative Names | T-cell surface glycoprotein CD4; CD4 |
UniProt ID | W5P8J4 |
Protein Refseq | The length of the protein is 527 amino acids long. The sequence is show below: MGPGTSLRHLFLVLQLVMLPAGTQGKAVVLGKAGGQAELPCQASQKKNIVFSWKDSSQSKILGSHNSFLHKGNTELSHRVESKKNLWDQGSFPLIIKNLQVTDSGTYTCEVDSKKLEVELKVFGLTASSDTRVLLGQSLTLTLESPSGSNPSVQWKGPGNNRKEELKSLSLAQVGLQDSGTWTCTISQSQQTLEIKIPIVVLAFQKAPETVYVKEGEQAEFSFPLTFEDENLSGELTWQQANKDSSSQSWVTFTLRNREVKVNKTHKDVKLHMGERLPLRLTLQRTLPQYAGSGTLTLDLTKGKLHQKVNLVVMTVTKSPNSLTCEVLGPSPPRLTLNLKLGNQSMKSSNQPKVVTELEPKAGMWQCLLSDQGKVLLESKIEVLPSEFIQAWPKLLPMVLGGIAGLALLTGSCIFCVKCWHRRVSELSLTSSRPHGALKTLRPVRAKVSHVYDLLLLWLPLPTAPSLTAGWAPSQIPGGGREGKAQSQFWDRWPPQPQPWPLPSPPSPPPPPPKRLLSEKKTCQCPQ. |
Reference
Reference | 1. Mackay, C. R., And, J. F. M., & Brandon, M. R. (1986). Three distinct subpopulations of sheep T lymphocytes. European journal of immunology, 16(1), 19-25. 2. Prowse, R. K., Chaplin, P., Robinson, H. C., & Spithill, T. W. (2002). Fasciola hepatica cathepsin L suppresses sheep lymphocyte proliferation in vitro and modulates surface CD4 expression on human and ovine T cells. Parasite immunology, 24(2), 57-66. |
See other products for " CD4 "
CBMOAB-00142FYA | Mouse Anti-Goat CD4 Antibody (CBMOAB-00142FYA) |
CBMOAB-00060FYA | Mouse Anti-Cattle CD4 Antibody (CBMOAB-00060FYA) |
CBMOAB-00058FYA | Mouse Anti-Cattle CD4 Antibody (CBMOAB-00058FYA) |
MOFY-0622-FY175 | Rabbit Anti-CD4 Antibody (MOFY-0622-FY175) |
CBMOAB-00150FYA | Mouse Anti-Horse CD4 Antibody (CBMOAB-00150FYA) |
MO-AB-24462R | Mouse Anti-Pig CD4 Antibody (MO-AB-24462R) |
MO-AB-29467W | Mouse Anti-Dog CD4 Antibody (MO-AB-29467W) |
CBMOAB-69695FYA | Mouse Anti-Zebrafish cd4 Antibody (CBMOAB-69695FYA) |
MO-AB-21077W | Mouse Anti-Chimpanzee CD4 Antibody (MO-AB-21077W) |
CBMOAB-00151FYA | Mouse Anti-Horse CD4 Antibody (CBMOAB-00151FYA) |
For Research Use Only | Not For Clinical Use.
Online Inquiry