Mouse Anti-smn1 Antibody (CBMOAB-06530FYB)

Cat: CBMOAB-06530FYB

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Lot Number

Product List
Specifications
Application Information
Target

Sub Cat	Clonality	Species Reactivity	Application	Clone	Conjugate	Size
CBMOAB-06530FYB	Monoclonal	Zebrafish (Danio rerio), C. elegans (Caenorhabditis elegans), Cat (Felis catus), Cattle (Bos taurus), Chimpanzee (Pan troglodytes), Dog (Canis lupus familiaris), Frog (Xenopus laevis), Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Primate, Frog (Xenopus), Rhesus (Macaca mulatta), Pig (Sus scrofa)	WB, ELISA	MO06530FYB		100 µg	Inquiry
Protein Refseq: The length of the protein is 285 amino acids long. The sequence is show below: MANGAEDVVFCRGTGQSDDSDIWDDTALIKAYDKAVASFKNALKGEDGATPQENDNPGKKRKNNKKNKSRKRCTAAPDKEWQVGDSCYAFWSEDGNLYTATITSFDQEKGTCVVFYTDYGNEEEQNLSDLLTEPPDVDEDALKTANVKETESSTEESDRSFHPTEVRSCKAKSKSNFPMGPPSWFPRFPPGPPPPPPHFKKMDGRRGEGPSLGWPPSLPGWPPMIPLGPPMIPPPPPMSPDFGEDDEALGSMLISWYMSGYHTGIYMGLRQGRKEAAASKKSHRK.
CBMOAB-09947HCB	Monoclonal	C. elegans (Caenorhabditis elegans)	WB, ELISA	MO09947HB		100 µg	Inquiry
Protein Refseq: The length of the protein is 207 amino acids long. The sequence is show below: MAKIWSKSGDMEVDDVWDDTELIKMYDESLQEISKNETSAKITSRKFKGEDGKMYTWKVGGKCMAPYEENGEVTDYPATIDTIGGADNLEVGVTFIYYGGQAVVQMKDLWLNEEAIADAVKAENDLQKTKKTSTVNSVAHSNSKSTSSAPNTSMPFPSFAPPVPPNIIAMAPVNQKEAMNSMLMSWYMSGYHTGYYQALADQKNVQN.
CBMOAB-58547FYA	Monoclonal	Rhesus (Macaca mulatta)	WB, ELISA	MO58547FYA		100 µg	Inquiry
Protein Refseq: The length of the protein is 262 amino acids long. The sequence is show below: MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDICETSGKPKTTPKRKPAKKNKSQKKNTAAPLKQWKVGDKCSAIWSEDGCIYPATIASVDFKRETCVVVYTGYGNREEQNLSDLLSPISEVANNIEQNAQENENESQVSTDESENSRSPGSKSDNIKSKSAPWNSFLPPPPPMPGPRLGPGKIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMGFRQNQKEGRCSHSLN.
MO-AB-07850H	Monoclonal	Frog (Xenopus laevis)	WB, ELISA	MO07850C		100 µg	Inquiry
Protein Refseq: The length of the protein is 282 amino acids long. The sequence is show below: MAGLEDGGEVLFRRGAGQSDDSDIWDDTALIKAYDKAVSSFKRALKNEDCTIGAETEEKNPRTKRKNNKKNRSRKKCNAAPLKKWRIGDTCNAVWSEDGNIYSATISSIDAKRGTCIVVYSGYGNSEEHSLADLRFPDTSEAESDQRDQEQEINGDEHSTDESDRSSRSHQSKDPQNRETPKSSQWNGQFPPVPPPFMPGFGRHGEKLDQAHPFLSGWPPPFLPGPPMIPPPPPMSPDACEDDEALGSMLISWYMSGYHTGYYLGLKQGRMESSIGKPPHQK.
MO-AB-08005W	Monoclonal	Cat (Felis catus)	WB, ELISA	MO08005W		100 µg	Inquiry
Protein Refseq: The length of the protein is 290 amino acids long. The sequence is show below: MAMGGGSGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDISEASDKPKGTPKRKPAKKNKSQKKNTTAALKQWKVGDKCSAIWSEDGCVYPATIASIDFKRETCVVVYTGYGNREEQNVSDLLSPASAVDNNVEQNAQENENESQISTDESENSCRSPGNKSNNVKSKATSWNSFLPPPPPMPGAGLGPAKPGLKFNGPPPPPPPPPHFLSCWLPPFPSGPPIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMGFKQNQKEGRCSHFN.
MO-AB-12808W	Monoclonal	Chimpanzee (Pan troglodytes)	WB, ELISA	MO12808W		100 µg	Inquiry
Protein Refseq: The length of the protein is 297 amino acids long. The sequence is show below: MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDICETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKRETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPLPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMGFRQNQKEGRCSHSLN.
MO-AB-20612R	Monoclonal	Cattle (Bos taurus)	WB, ELISA	MO20612R		100 µg	Inquiry
Protein Refseq: The length of the protein is 287 amino acids long. The sequence is show below: MGGGGGGFPEPEDSVLFRRGTGESDDSDVWDDTALIKAYDKAVASFKHALKNGDISEASEKPKGTPKRKSAKNKSQRKNTTSPSKQWKVGDNCCAIWSEDGCIYPATIASIDFKRETCVVVYTGYGNREEQNLSDLLSPTSEVANIEQNAQENENESQISTDESENSSRSPLNKPNNIRSRAAPWNSFLPPPPHMPRSGLGPGKSGLNFSGPPPPPPPPPHFLSRWLPPFPAGPPMIPPPPPICPDSLDDADALG.
MO-AB-30256R	Monoclonal	Pig (Sus scrofa)	WB, ELISA	MO30256R		100 µg	Inquiry
Protein Refseq: The length of the protein is 294 amino acids long. The sequence is show below: MAMGGGGGGSGVPEAEDSVLFRRGAGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDISEASDKPKATPKRKPPKKNKSQKKNTTASLKQWKVGDRCSAIWSEDGCIYPATIASIDFKRETCIVVYTGYGNREEQNLSDLLSPTSEVANNIEENAQENENESQISTDESESSSRSPGNKPNNIKSKAAPWNSFLPPPPPMPGAGLGPRKPGLKFNGPPPPPPPPPPHFLSCWLPPFPSGPPIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMGFKQNQKEGRCSHFN.
MO-AB-33457W	Monoclonal	Dog (Canis lupus familiaris)	WB, ELISA	MO33457W		100 µg	Inquiry
Protein Refseq: The length of the protein is 287 amino acids long. The sequence is show below: MGGGGGLPEPEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDISEASDKPKSTPKRKPAKKNKSQKKNATTALKQWKVGDKCSAVWSEDGCIYPATIASIDFKRETCVVVYTGYGNREEQNVSDLLSPACEVANNVEQDTQENENESQISTDESENSSRSPGNKPNNIKSKAAPWNSFLPPPPPMSGSGLGPGKPGVKFSGPPPPPPPPHFLSCWLPPFPSGPPIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMGFKQNQKEGRCSHFN.
MO-NAB-00362W	Monoclonal	Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Primate, Frog (Xenopus), Zebrafish (Danio rerio)	WB, ELISA, FC, IF, IHC, IHC-P, IP	NW0288		100 µg	Inquiry
MO-DKB-01415W	Polyclonal	Human (Homo sapiens), Rhesus (Macaca mulatta)	WB, IF			100 µg	Inquiry

Specifications

Host species	Mouse (Mus musculus)
Species Reactivity	Zebrafish (Danio rerio), C. elegans (Caenorhabditis elegans), Cat (Felis catus), Cattle (Bos taurus), Chimpanzee (Pan troglodytes), Dog (Canis lupus familiaris), Frog (Xenopus laevis), Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Primate, Frog (Xenopus), Rhesus (Macaca mulatta), Pig (Sus scrofa)
Clone	MO06530FYB
Specificity	This antibody binds to Zebrafish smn1.
Format	Liquid or Lyophilized
Storage	Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use
Purity	> 90% was determined by SDS-PAGE
Purification	Purified with Protein A or G affinity chromatography
Cellular Localization	Nucleus; Other locations

Application Information

Application	WB, ELISA
Application Notes	ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

Introduction	This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy; mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Multiple transcript variants encoding distinct isoforms have been described.
Product Overview	Mouse Anti-Zebrafish smn1 Antibody is a mouse antibody against smn1. It can be used for smn1 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative Names	Survival motor neuron protein; smn1; sm
UniProt ID	O93420
Protein Refseq	The length of the protein is 285 amino acids long. The sequence is show below: MANGAEDVVFCRGTGQSDDSDIWDDTALIKAYDKAVASFKNALKGEDGATPQENDNPGKKRKNNKKNKSRKRCTAAPDKEWQVGDSCYAFWSEDGNLYTATITSFDQEKGTCVVFYTDYGNEEEQNLSDLLTEPPDVDEDALKTANVKETESSTEESDRSFHPTEVRSCKAKSKSNFPMGPPSWFPRFPPGPPPPPPHFKKMDGRRGEGPSLGWPPSLPGWPPMIPLGPPMIPPPPPMSPDFGEDDEALGSMLISWYMSGYHTGIYMGLRQGRKEAAASKKSHRK.

For Research Use Only | Not For Clinical Use.

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