Anti-UBB Antibody (Cat MO-MMB-0546), Mouse IgG1


Cat: MO-MMB-0546
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityCattle (Bos taurus), C. elegans (Caenorhabditis elegans), Chicken (Gallus gallus), Fruit fly (Drosophila melanogaster), Human (Homo sapiens)
CloneMbi-1
SpecificityThis antibody is binds to D. melanogaster UBB. This antibody detects about 8.5 kDa Ubiquitin.
ImmunogenThe immunogen is the purified ubiquitin conjugated with glutaraldehyde to keyhole limpet hemocyanin.
FormatLiquid or Lyophilized
BufferLyophilized with 5% trehalose
Regulatory StatusFor Research Use Only
ShippingGel Pack
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use

Application Information

ApplicationIHC-Fr, IHC-P, WB
Application NotesIHC: 1:500
WB: 1:500-1000
The optimal dilution should be determined by the end user.

Target

IntroductionUbiquitin is a highly conserved 76 amino acid protein with an estimated molecular weight of 8.56 kDa, which plays a central role in regulating protein degradation. It is a protein modifier that can be covalently linked to the target lysine as a monomer or as a lysine-linked polymer. Depending on the lysine used for assembly, several types of polymer chains can be formed. Attaching to proteins as polymers will cause them to be degraded by 26S proteosome; a complex multi-catalytic cytosolic and nuclear protease. Polymers attached as monomers or as alternatives to proteins will not cause proteasome degradation and may be required for many functions, including maintenance of color structure, gene expression regulation, stress response, ribosome biogenesis, and DNA repair. Ubiquitin is synthesized as a polyubiquitin precursor with precise head-to-tail repeats, and the number of repeats varies with species and strains. In some species, there is a final amino acid after the last repetition, which is cysteine ​​in cattle. Some ubiquitin genes contain a single copy of ubiquitin fused to ribosomal protein (L40 or S27a).
Product OverviewThis product is a mouse antibody against the UBB. It can be used for UBB detection in IHC-Frozen, IHC-Paraffin-embedded, Western Blot.
Alternative NamesRPS27A; UBA52; UBB; UBC; Polyubiquitin-B; Polyubiquitin-C
UniProt IDP0CG47
For Research Use Only | Not For Clinical Use.
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