Myeloproliferative leukemia virus oncogene
In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
Mouse Anti-E. coli mpl Antibody (CBMOAB-1732YC) (CAT#: CBMOAB-1732YC)
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- Host species: Mouse
- Species Reactivity: E. coli (Escherichia coli )
- Application: WB, ELISA
- Protein: UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligase
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, None, PE, PerCP
- Alternative Names: UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligase, EC 6.3.2.45, Murein peptide ligase, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase, mpl, yjfG, b4233 JW4192
Mouse Anti-Zebrafish mpl Antibody (CBMOAB-87254FYA) (CAT#: CBMOAB-87254FYA)
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- Host species: Mouse
- Species Reactivity: Zebrafish (Danio rerio)
- Application: WB, ELISA
- Protein: Submitted name: MPL proto-oncogene, thrombopoietin receptor
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: Putative thrombopoietin receptor b, mpl, mpll tpor.
Mouse Anti-Rhesus MPL Antibody (CBMOAB-51625FYA) (CAT#: CBMOAB-51625FYA)
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- Host species: Mouse
- Species Reactivity: Rhesus (Macaca mulatta)
- Application: WB, ELISA
- Protein: Fibronectin type-III domain-containing protein
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: MPL
Mouse Anti-Rabbit MPL Antibody (MO-AB-08858Y) (CAT#: MO-AB-08858Y)
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- Host species: Mouse
- Species Reactivity: Rabbit (Oryctolagus cuniculus)
- Application: WB, ELISA
- Protein: Submitted name: Myeloproliferative leukemia virus oncogene
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: Myeloproliferative leukemia virus oncogene, MPL
Mouse Anti-Rat MPL Antibody (MO-AB-27163H) (CAT#: MO-AB-27163H)
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- Host species: Mouse
- Species Reactivity: Rat (Rattus norvegicus)
- Application: WB, ELISA
- Protein: Submitted name: Myeloproliferative leukemia virus oncogene
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: Myeloproliferative leukemia virus oncogene, Mpl
Mouse Anti-Guinea pig MPL Antibody (MO-AB-42096W) (CAT#: MO-AB-42096W)
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- Host species: Mouse
- Species Reactivity: Guinea pig (Cavia porcellus)
- Application: WB, ELISA
- Protein: Submitted name: Myeloproliferative leukemia virus oncogene
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: Myeloproliferative leukemia virus oncogene, MPL
Mouse Anti-Marmoset MPL Antibody (MO-AB-59266W) (CAT#: MO-AB-59266W)
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- Host species: Mouse
- Species Reactivity: Marmoset
- Application: WB, ELISA
- Protein: Submitted name: Myeloproliferative leukemia virus oncogene
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: Myeloproliferative leukemia virus oncogene, MPL
