Protein tyrosine phosphatase, receptor type, C
Protein tyrosine phosphatase, receptor type, C, also known as PTPRC, is an enzyme encoded by the PTPRC gene in humans. PTPRC is also called CD45 antigen (CD stands for differentiation cluster) and was originally called Leukocyte Common Antigen (LCA).
The protein product of this gene, most famously CD45, is a member of the protein tyrosine phosphatase (PTP) family. PTP is a signaling molecule that regulates various cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
CD45 is a type I transmembrane protein and exists in various isoforms in all differentiated hematopoietic cells (except red blood cells and plasma cells). CD45 has been shown to be an important regulator of T cell and B cell antigen receptor signal transduction. It plays a role by directly interacting with the components of the antigen receptor complex through its extracellular domain (a form of co-stimulation), or through its cytoplasmic domain to activate various Src family kinases required for antigen receptor signal transduction. CD45 can also inhibit JAK kinase, so it can be used as a negative regulator of cytokine receptor signal transduction.
Mouse Anti-PTPRC Antibody (CBMOAB-00050FYA) (CAT#: CBMOAB-00050FYA)
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- Host species: Mouse
- Species Reactivity: Cattle (Bos taurus), Alpaca (Vicugna pacos), Llama (camel), Chicken (Gallus gallus), Chimpanzee (Pan troglodytes), Dog (Canis lupus familiaris), Horse (Equus caballus), Human, Horse, Mouse, Feline, Rhesus (Macaca mulatta), Zebrafish (Danio rerio)
- Application: FC
- Size: 100µg
- Conjugate: None
- Alternative Names: B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200
Mouse Anti-PTPRC Antibody (CBMOAB-00180FYA) (CAT#: CBMOAB-00180FYA)
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- Host species: Mouse
- Species Reactivity: Rabbit (Oryctolagus cuniculus), Alpaca (Vicugna pacos), Llama (camel), Cattle (Bos taurus), Chicken (Gallus gallus), Chimpanzee (Pan troglodytes), Dog (Canis lupus familiaris), Horse (Equus caballus), Human, Horse, Mouse, Feline, Rhesus (Macaca mulatta), Zebrafish (Danio rerio)
- Application: FC
- Size: 100µg
- Conjugate: None
- Alternative Names: B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200
