Mouse Anti-C. elegans PAT2 Antibody (CBMOAB-08191HCB)


Cat: CBMOAB-08191HCB
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityC. elegans (Caenorhabditis elegans)
CloneMO08191HB
SpecificityThis antibody binds to C. elegans PAT2.
FormatLyophilized
StorageStore at 4°C: short-term (1-2 weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationPlasma Membrane; Other locations

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionRequired for muscle development probably through the regulation of the actin-myosin cytoskeleton (PubMed:8106547, PubMed:12915588). Component of an integrin containing attachment complex, which is required for muscle maintenance (PubMed:22253611). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably through lamins such as epi-1, lam-2 and unc-52 (PubMed:16495308). Required for distal tip cell migration and dorsal pathfinding (PubMed:17606640). Required for egg-laying (PubMed:12915588). May play a role in cell motility and cell-cell interactions (By similarity). Plays a role in vulval development (PubMed:28135265). Probably within the alpha pat-2/beta pat-3 integrin receptor complex, plays a role in the negative regulation of let-23 signaling and vulval induction. This is probably partly by restricting the mobility of the let-23 receptor on the plasma membrane of vulval cells which thereby attenuates let-23 signaling (PubMed:28135265).
Product OverviewMouse Anti-C. elegans PAT2 (clone MO08191HB) Antibody (CBMOAB-08191HCB) is a mouse antibody against PAT2. It can be used for PAT2 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesIntegrin alpha pat-2; Paralyzed arrest at two-fold protein 2; pat-2
UniProt IDP34446
Protein RefseqThe length of the protein is 1226 amino acids long. The sequence is show below: MREGSFPRRIGLLLGLLGLLAGVATFNIDTKNVVVHHMAGNYFGYSLDFYHEQKGMPVLVVGAPEAESNNPNLAGIRRPGAVYACSVNRATCREVHVDKMKGNLKKLNGSHLVPIEEKSHQFFGATVRSNDKHDKIVVCAPKYTYFYSKFEVIEPVGTCFYAENGFDNAEEFSSCKQEPARHGRHRLGYGQCGFSAAVPGKKNQNRVFIGAPGVWYWQGAMFSQNIKNQTDRPNTEYGSKEYDHDMMGYSTATGDFDGDGIDDIVAGVPRGNDLHGKLVLYTSKLKMMINLTDEVSTQHGQYCGGSVAVADVNKDGRDDIIMGCPFYTDYGSVKDAKTQERKPQYDVGKVIVMLQTAPGVFGKQIAVVGDDQWGRFGHAVAAAGDLNLDGYNDVIVGAPYAGKNKQGAVYVIHGSKDGVRELPTQKIEGANIGHGNIKSFGFSLTGNEDVDGNGMPDIAVGAWKSGNAAVLLTKPVVTVTGQTEPESALISVEDKNCDVDGKLGKQACKHINTCFKYEGKGDTPNDLEFDLRFNLDDHSPEPRAYFLQKDVKSDRSIKVAQGSKTRDHPSSIEQRVRLEKGRQKCFRHRFFASSTMKDKLSPIHWSVNYTYVESKTGKLRGDKLEPAIDTTVPLSFQNKINIANNCGKDDLCVPDLKVTAVADREKFLLGTQDNTMLINVTVQNGGEDSYETKLYFDVPQGFEYGGIESVGGDGSKSAPACSPTSDEPDSDGKWTFACDLGNPLPANKVVSSVVRVTASSDKPPLAPISINAHVNSSNDEEAHTVADNKVTFTIPVDFKNQLSLNGRSNPEQVDFSMTNKTRVDAFDDNEIGPVVSHLYQISNRGPSEVDSATLDIFWPSFSTEGGHLLYIITEPVVNPPNKGRCRVKQLQNVNPLNLRITNEHVPTEPPVAKTPNEYSREEDDESYEDETTTQSQSTRHQSTQHQTHHQSGPVHVYEKDEEKIRQNTGNWQYVEDKKKKGDYEYIPDDQEYDGDDFEEEDDEDFDRAGSKRVKRNPTPKKKKKGGEHRGEPRSDKARFSDLREAVKLSKEAGGVVDYKGPLSRASVDCNSLRCTHIECDIYDLKEDEFVLVEIFSRLYTNTLVDEKNPGGDISSLALARVTSTKYNLPHKPTLITAVSTNMNAIASEEGRDLPWWLYLLAILIGLAILILLILLLWRCGFFKRNRPPTEHAELRADRQPNAQYADSQSRYTSQDQYNQGRHGQML.

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For Research Use Only | Not For Clinical Use.

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