Bacteriophage Antibody

Supported by in-house scientists and first-in-class technical platform, Creative Biolabs is confident in providing a series of high-quality Bacteriophages antibody products and services to assist biologists in genetics and molecular biology research.

Background

Bacteriophages, a ubiquitous feature of prokaryotes, are the most abundant organisms in the biosphere.

Phage was discovered 100 years ago and has been a key tool in biological research ever since. Bacteriophages were originally used as model organism in genetics and molecular biology and are now considered to be one of the main drivers of bacterial evolution and diversification. The introduction of sequencing technology, phage genomics and metagenomics has highlighted their tremendous diversity and role in controlling ecosystems in various environments. Due to their specificity, phage genomes are now also used as therapeutic agents, potentially providing an alternative to conventional antibiotics.

Research area of Bacteriophage as model organism

• Bacteriophage is considered to be useful in many fundamental biological concept formations.

These include clear identification of nucleic acids as the genetic material; Definition of the natural genetic code of the gene demonstration triad through fine structure of recombination, mutation, and functional analysis; mRNA discovery; the significance of recombination in DNA replication; prokaryote’s self-splicing introns and many others. As T4 phages completely inhibit host gene expression, allowing researchers to distinguish between phage and host macromolecule synthesis, is an excellent model system.

• Bacteriophages play an important role in vaccine research.

T4 bacteriophages are used to deliver vaccines or as delivery vehicles for DNA vaccines or as a form in which immunogenic peptides are attached to the modified coat proteins of T4 bacteriophage. Display of T4 bacteriophage helps to identify immunogenic antigens or epitopes on displayed peptides, laying the foundation for the development of peptide vaccines.

Fig.1 The principle, process and application of phage display technology.
• T4 bacteriophage display technology is an important molecular tool with a key impact on drug discovery, immunology, pharmacology, and plant science.

Display technology is a technique for the presence of foreign proteins, peptides, or antibody fragments on the surface of T4 bacteriophage particles. The heterologous protein or peptide is cloned into phagemid genome or a T4 bacteriophage by transcriptional fusion. Thus, T4 bacteriophages become expression vehicles along with the nucleotide sequence in the protein they encode, allowing the gene sequence to be retrieved and also have the ability to replicate.

• Using bacteriophages as an alternative method is proposed to control pathogenic bacteria.

Many studies have shown successful use of bacteriophages in different fields such as food safety, agriculture, aquaculture, and even human health. Several companies are commercializing bacteriophages or bacteriophage-based therapeutic products. In the 1940s The Eli Lilly Company developed T4 bacteriophage products against Escherichia coli for human use.

Scientists at Creative Biolabs are dedicated to bringing together years of valuable experience to help our clients shorten the research journey. We are committed to the Bacteriophages antibody products and services and dedicated to reducing the overall project development timeline for our clients.

Our provided hot target antibody products include the followings, but not limited to:

Reference

1. Deng X Y, Wang L, You X L, et al. Advances in the T7 phage display system (Review). Mol Med Rep. 2018, 1;17(1):714-720.