Immunology

Immunology is a broad and complex research area that encompasses innate immunity, adaptive immunity, and immune regulation in the naive state and response to infection and disease. Creative Biolabs offers an extensive collection of immunology antibodies, encompassing core research areas, including cell marker and receptor antibodies, cytokine antibodies, and other immunology antibodies.

Background

Immunology is the study focused on the immune system of higher organisms in relation to disease. It protects us from infection through various lines of defense. Generally, the immune system of higher organisms can be divided into two primary response systems: innate and adaptive immune responses. The adaptive immune response is further divided into cell-mediated and antibody-mediated responses. When a subset of sensitized lymphocytes or white blood cells directly attack material that has been determined to be foreign to the body, the cell-mediated response is produced. The antibody-mediated response involves the transformation of a subset of lymphocytes into cells that produce and secrete specific antibodies against the foreign material. These two immune responses are triggered when foreign material is introduced into the host. If the immune system is destroyed, it can result in diseases, such as autoimmunity, allergy, and cancer.

Research Area of Immunology in Different Species

• Zebrafish
• The innate and adaptive immune systems of the zebrafish are highly conserved when compared to mammals. Therefore, screens in zebrafish promise to uncover genes involved in T cell development, thymic organogenesis, and immunity to infections.
• Coupled with novel approaches probing autoimmunity and leukemogenesis, zebrafish will be instrumental in elucidating physiology and pathology of the immune system.
• Recent technical advances, such as hematopoietic lineage labeling, morpholino gene knockdown, and gene-inactivation through TILLING, will be conducive to tailoring the zebrafish into a versatile tool for immunologic research.
• Establishing the zebrafish as a model system provides an alternative and complementary tool to the use of mice and will further our understanding of the immune system.
• Caenorhabditis elegans (C. elegans)
• C. elegans relies solely on its innate immune system to defend itself against pathogens.
• The innate immune system of C. elegans employs evolutionarily conserved signaling pathways.
• The immune system of C. elegans contains only some of the most ancestral signaling networks, which has experimentally advantageous in terms of detailed characterization of the immune signaling cascades.
• Systemic interactions between innate immunity and other signaling systems have been established by using C. elegans, such as stress responses and mechanisms involved in the regulation of longevity.
• The relatively low complexity of the nematode system also provides extended possibilities for dissecting non-conventional aspects of innate immune responses. For example, a novel function of innate immunity in integrating cell-autonomous hazards such as germline DNA damage with systemic stress resistance has been uncovered.

Our provided featured target antibody products including but not limited to: