Mouse Anti-CSF1R Antibody (CBMOAB-39957FYA)

Cat: CBMOAB-39957FYA

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Product List
Specifications
Application Information
Target

Sub Cat	Clonality	Species Reactivity	Application	Clone	Conjugate	Size
CBMOAB-39957FYA	Monoclonal	Rhesus (Macaca mulatta), Cat (Felis catus), Cattle (Bos taurus), Ferret (Mustela Putorius Furo), Horse (Equus caballus), Pig (Sus scrofa), Zebrafish (Danio rerio)	WB, ELISA	MO39957FYA		100 µg	Inquiry
Protein Refseq: The length of the protein is 976 amino acids long. The sequence is show below: MGPGVLLLLLVVTAWHGQGIPVIEPSGPELVVKPGETVTLRCVGNGSVEWDGPISPHWTLYSDGPSSVLTTTNATFQNTRTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAKEVVVFEDQDALLPCLLTDPVLEAGVSLVRLRGRPLMRHTNYSFSPWHGFTIHRAKFIQGQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASNIDVDFDVFLQHNTTKLAIPQRSDFHDNRYQKVLTLSLGQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLDLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGCYSFLARNPGGWRALTFELTLRYPPEVSVIWTSINGSGTLLCAASGYPQPNVTWLQCAGHTDRCDEAQVLQVWVDPHPEVLSQEPFQKVTVQSLLTAETLEHNQTYECRAHNSVGSGSWAFIPISAGARTHPPDEFLFTPVVVACMSVMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGADYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELWDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSLLQEQAQEDRRERDYTNLPSSSRSGGSGSGSSSSSSEPEEESSSEHLACCEQGDIAQPLLQPNNYQFC.
CBMOAB-71958FYA	Monoclonal	Zebrafish (Danio rerio)	WB, ELISA	MO71958FYA		100 µg	Inquiry
Protein Refseq: The length of the protein is 977 amino acids long. The sequence is show below: MFFALLFLIGILLGQVQGWSEPRIRLSSGALAGTDVILESGSPLQLVCEGDGPVTFLPRLAKHKRYISKEVGKIRSFRVEKTTVDFTGTYKCVYMNGNDSNLSSSVHVFVRDSRVLFVSPSTSLRYVRKEGEDLLLPCLLTDPEATDFTFRMDNGSAAPYGMNITYDPRKGVLIRNVHPGFNADYICCARIGGAEKVSKIFSINIIQRLRFPPYVYLKRNEYVKLVGERLQISCTTNNPNFYYNVTWTHSSRMLPKAEEKSTMEGDRLAIESILTIPSVQLSHTGNITCTGQNEAGANSSTTQLLVVEEPYIRLSPKLSSKLTHRGLSIEVSEGDDVDLGVLIEAYPPLTSHKWETPTSHNASLPENRFFNHNDRYEALLLLKRLNFEEIGQYTLNVKNSMKSASITFDIKMYTKPVARVKWENVTTLSCRSYGYPAPSILWYQCTGIRTTCPENTTDLQPIQTQTVEFQKESFGAVGVESVLTVGPNRRMTVVCVAFNLVGQGSDTFSMEVSDQIFTSAMCGSTVAMVVLGLLLIFMIYKYKQKPRYEIRWKIIEATNGNNYTFIDPTQLPYNEKWEFPRDKLKLGKTLGAGAFGKVVEATAYGLGKEDNITRVAVKMLKASAHPDEREALMSELKILSHLGQHKNIVNLLGACTHGGPVLVITEYCCHGDLLNFLRSKAENFLNFVMTIPNFPEPMTDYKNVSTERMFVRSDSGISSTCSDHYLDMRPVTSRPTNSALDSSSECQEDSWPLDMDDLLRFSSQVAQGLDFLAAKNCIHRDVAARNVLLTNSRVAKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFECVYTVQSDVWSYGIMLWEIFSLGKSPYPNILVDSKFYKMIKCGYQMSRPDFAPPEMYTIMKMCWNLDAAERPTFSKISQMIQRMLGETSEQQDTQEYKNIPTEAEAEQQLESCDPVKHEDESFETSCDQEEEDQPLMKPNNYQFC.
MO-AB-08504W	Monoclonal	Cat (Felis catus)	WB, ELISA	MO08504W		100 µg	Inquiry
Protein Refseq: The length of the protein is 982 amino acids long. The sequence is show below: MGPRALLVLLVATAWHAQGVPVIQPSGPELVVEPGTTVTLRCVGNGSVEWDGPISPHWNLDLDPPSSILTTNNATFQNTGTYHCTEPGNPQGGNATIHLYVKDPARPWKVLAQEVTVLEGQDALLPCLLTDPALEAGVSLVRVRGRPVLRQTNYSFSPWHGFTIHKAKFIENHVYQCSARVDGRTVTSMGIWLKVQKDISGPATLTLEPAELVRIQGEAAQIVCSASNIDVNFDVSLRHGDTKLTISQQSDFHDNRYQKVLTLNLDHVSFQDAGNYSCTATNAWGNHSASMVFRVVESAYLNLTSEQSLLQEVTVGEKVDLQVKVEAYPGLESFNWTYLGPFSDYQDKLDFVTIKDTYRYTSTLSLPRLKRSEAGRYSFLARNAGGQNALTFELTLRYPPEVRVTMTLINGSDTLLCEASGYPQPSVTWVQCRSHTDRCDESAGLVLEDSHSEVLSQVPFHEVIVHSLLAIGTLEHNRTYECRAFNSVGNSSQTFWPISIGAHTQLPDELLFTPVLLTCMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRQAEAMLGPSLSVAQDPEAGAGYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSSNDSFSEEDLGKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGRVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTRRPTFQQICSLLQKQAQEDRRVPNYTNLPSSSSSSSSSSSSSSCRTGSGGGSSSEPEEESSSEHLACCEQGDIAQPLLQPNNYQFC.
MO-AB-10796R	Monoclonal	Cattle (Bos taurus)	WB, ELISA	MO10796R		100 µg	Inquiry
Protein Refseq: The length of the protein is 964 amino acids long. The sequence is show below: MGPRTLLILLVVTAWHGQGVPVIEPSGPELVVEPGTAVTLRCTSNGSVKWDGPVSPYWTLDSDAPRSILTTNNATFLHTGTYRCTEPGDPLAGTATIHLYVKDPARPWRVLAEEVTVLEGQDALLPCLLTDPALEAGVSLVRVRGRSVLRQTSYSFSPWYGFTIHKAKFIESQDYECSVRVAGRVVKSLSIRLKVQKVIPGPPTLTLEPEELVRIQGETAKIVCSASDVDVNFDVFLQRGDTKLAISQQSDFRDN.
MO-AB-24906R	Monoclonal	Pig (Sus scrofa)	WB, ELISA	MO24906R		100 µg	Inquiry
Protein Refseq: The length of the protein is 969 amino acids long. The sequence is show below: MGLGTLLLLLAVTAWPGQGVPVIEPSGPELVVEPGAAVTLRCVSNVSVEWDGPISRSWTLDPDAPSSALTTNNATFQNTGTYRCTELGDPLGGSATIHLYVKDHRRPWRVLAPEVTVLEGQDARLPCLLTDPALAGGVSLALLRRLSVLPGRAVLRQTNYSFSPWHGFTIHKAKFIEGQDYACTVLVDGRVVWNSVRLNVQKVIPGPPTLTLKPTELVRIRGEAAQIVCSATDVDVHFEVFLHRGDTKLAISQQSDFHDNRYQKVLTLDLDPVGFQDAGNYTCMATNARGTHATSMVFRVVEGAYLTLTSEQSLRQEVAVGEKLDLKVKVEAYPSLQSFNWTYQGPFSDQQPELSFETSKDTYRYASTLTLPRLKPSEAGRYSFLARNARGEGVLTFELTLLYPPEVRITWSLVNGSRALVCQASGYPQPNVTWVWCGGHTDRCEGAGVLVQEALGPEVLSQEPFHKATVQRLLAVGTLERNRTYECRACNSLGNSSHAFQPVSVAAQVHSPDEPLFTPVLVACVSIMALLLLLLLLLLYKYKKKPKYQVRWKIIESFAGNSYTFIDPTQLPYSEKWEFPRNKLQFGKTLGAGAFGKVVEATAFGLGQEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGPHENTVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPGLNPGQSPEPGPGYKNIPLEKKYTRRDSGFSSQGVDAYVEMRPVSTSSSNDSFSEQDLDKEDGRPLELCDLLRFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTRRPTFQQICSLLQEQSHGDQRARDYSNLPSSSSSSSEPEEGSSGEHLACCEQGDAAQPLLQPNTYQFC.
MO-AB-34626W	Monoclonal	Ferret (Mustela Putorius Furo)	WB, ELISA	MO34626W		100 µg	Inquiry
Protein Refseq: The length of the protein is 978 amino acids long. The sequence is show below: MGPGALLVLLGATTWRVQGVPVIEPSGPELVVEPGTTVTLRCVGNGSMEWDGPIFPYWNLDTEASSSTLTTNNATFLNTGTYRCTEPGGPLRDSAIIHLYVKDPVRPWKVLAEEVTVMEGQDALLPCLLTDPELEAGVSLMRVRGRPVLRQTNYSFSPWYGFTIHKAQFMETHGYQCNARVGGSTVTSKSIWLKVQKVIPGPPTLTLEPAELVRIQGETAKIVCAASNVDVSFDVFLQHGDTKLTIPQQSDFQGNQYQKVLTLELDHVGFQDAGNYSCVATNVRGINSRSMVFRVVERAYLNLTSKQNLLQEVTVGEKVDLQVQVEAYPGLQGWNWTYLGPFSDHQSKLNFVMMKDTYRYTSILSLPRLKPSEAGRYSFLARNTGGESSLTFELTLRYPPEVRVTWTVVNGSDALLCDASGYPQPNVTWLECRSHMDRCDEAQVLVLEDSQSQVLSREPFHKVIVHSLLAMGSLEHNRTYECQALNSVGNSSQAFRPISVGAHVQLSDEPLFTPVLVTCMSIMALLLLLLLLLFYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGTEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSVGQDPEAGAGYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSSNDSFSEQDMDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTRRPTFQQICSLLQEQAPADRRAPDYTNLPSSSSSSGSGSGGSGSGSGGGSSSEPESSSENLACCEQGDIAQPLLQPNNYQFC.
MO-AB-44204W	Monoclonal	Horse (Equus caballus)	WB, ELISA	MO44204W		100 µg	Inquiry
Protein Refseq: The length of the protein is968 amino acids long. The sequence is show below: MGLGALLVLLVATAWHGQGVPVIQPSGPELIVEPGTRVTLRCVGNGSVEWDGPISPSWTLDPDAPGSILTTNNATFQNTGTYRCTEPGDPLGGSATIHLFVKDPVRPWKVLAEEVTVLEGQDALLPCLLTDPALEAGVSLMRVRGRPVLRQTSYSFSLWHGFTIHKAKFIESQDYQCSARVDGRTATSISIRLKVQKVVPGPPTLTLEPAELVRIQGETAQIVCSASDVDVNFDVFLQHEDTKLTISQQSDFRDNRYHKVLTLSLGHVGFQDAGSYSCVATNAQGVRSSSMVFRVVESAYLNLTSEQNLLQEVTVGEKLNLKVKVEAYPGLQGFNWTYWGPFSDHPPKLTFTTVEDTYRYSSTLSLPRLKSSEAGRYSFLARNAKGEETLTFELTLRYPPEVTVSRALINGSEALLCVASGYPQPNVTWLQCGGRTERCDDAQVLVLEDSHPEVLSQEPFHKVTVQSQLAVGTLEYNRTYQCRAHNSMGNSSQAFWSISVGASMQPPDEPLFTPVLVTCMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSQGQDLEAGTGYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSSNDSFSEQDLDKEDGWPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGRVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCIYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICCFLQEQTQVDRREDYTNLPSSSSSGSSGSSSEPEEESSSEHLACCEQGDIAQPLLQPNNYQFC.

Specifications

Host species	Mouse (Mus musculus)
Species Reactivity	Rhesus (Macaca mulatta), Cat (Felis catus), Cattle (Bos taurus), Ferret (Mustela Putorius Furo), Horse (Equus caballus), Pig (Sus scrofa), Zebrafish (Danio rerio)
Clone	MO39957FYA
Specificity	This antibody binds to Rhesus CSF1R.
Format	Liquid or Lyophilized
Storage	Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use
Purity	> 90% was determined by SDS-PAGE
Purification	Purified with Protein A or G affinity chromatography

Application Information

Application	WB, ELISA
Application Notes	ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

Introduction	Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway (By similarity). Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor (By similarity). In the central nervous system, may play a role in the development of microglia macrophages (By similarity).
Product Overview	Mouse Anti-Rhesus CSF1R Antibody is a mouse antibody against CSF1R. It can be used for CSF1R detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative Names	Macrophage colony-stimulating factor 1 receptor; CSF1R
UniProt ID	H9FQ91
Protein Refseq	The length of the protein is 976 amino acids long. The sequence is show below: MGPGVLLLLLVVTAWHGQGIPVIEPSGPELVVKPGETVTLRCVGNGSVEWDGPISPHWTLYSDGPSSVLTTTNATFQNTRTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAKEVVVFEDQDALLPCLLTDPVLEAGVSLVRLRGRPLMRHTNYSFSPWHGFTIHRAKFIQGQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASNIDVDFDVFLQHNTTKLAIPQRSDFHDNRYQKVLTLSLGQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLDLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGCYSFLARNPGGWRALTFELTLRYPPEVSVIWTSINGSGTLLCAASGYPQPNVTWLQCAGHTDRCDEAQVLQVWVDPHPEVLSQEPFQKVTVQSLLTAETLEHNQTYECRAHNSVGSGSWAFIPISAGARTHPPDEFLFTPVVVACMSVMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGADYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELWDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSLLQEQAQEDRRERDYTNLPSSSRSGGSGSGSSSSSSEPEEESSSEHLACCEQGDIAQPLLQPNNYQFC.

For Research Use Only | Not For Clinical Use.

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