C. elegans Antibody Products

Supported by in-house scientists and first-in-class technical platform, Creative Biolabs offers C. elegans antibody for scientist to establish a broader context and improved tools for studying its biology.

Background

Caenorhabditis elegans is a nematode (roundworm) that lives in soil and is used as a model organism in molecular genetics and developmental biology. It is hermaphrodite (can be self-fertilized) and transparent and can map the location and fate of every cell in the body.

Caenorhabditis elegans is an important model system for biological research in many fields such as genomics, cell biology, neuroscience and aging. Its many advantages include short life cycle, compact genome, stereotyped development, easy reproduction and small size. Caenorhabditis elegans is suitable for genetic crossing as each adult produces a large number of offspring. Under optimal conditions, its life cycle is approximately 3 days. They can be raised in laboratories and grown on agar plates or liquid cultures with E. coli as food source. Since C. elegans is transparent throughout its life cycle, it can be inspected at the cellular level of live preparations with a differential interference contrast (DIC) microscope. The anatomical description of the entire animal has been completed under the electron microscope, and a complete cell lineage that remains unchanged between animals has been established.

Why choose C. elegans as a model organism?

• C. elegans as a model for mitochondrial diseases.

Studies using Caenorhabditis elegans found that human genes responsible for a variety of mitochondrial diseases have orthologous genes in Caenorhabditis elegans, making it possible to use C. elegans as a model organism for studying mitochondrial diseases.

• C. elegans is an attractive in vivo model for the whole organism to be used to identify the antioxidative activity of natural compounds.

In C. elegans, oxidative stress signal pathways are highly conserved, including the insulin signaling pathway, TOR signaling pathway, autophagy pathway, as well as active oxygen detoxification mechanism such as superoxide dismutase and catalase.

Fig.1 The fields of C. elegans used for the screening natural compounds.
• C. elegans provides a unique opportunity to study the function of the nervous system.

Nervous system is extremely simple consisting of only 302 neurons, and all the chemical and electrical synapses have been identified by successive section reconstruction of electron micrographs. This whole map of connectome contributes to generate and test hypotheses for how a behavior is encoded by the neural circuitry.

• C. elegans can be a candidate for the study of understanding the role of genetics in modulating aging.

There are several unique characteristics that serve C. elegans an ideal model organism for studying aging. Firstly, the model has a very short lifespan (~3 weeks) invariantly, which helps to identify mutants with shorter or longer average lifespans. Secondly, the somatic cells in adult are postmitotic, which makes it possible to study chronological aging. In addition, some important signaling pathways related aging and longevity, such as insulin/IGF-1 and dietary restriction (DR), have also been extensively studied to analyze the molecular mechanisms involved of aging.

• C. elegans as a model for immunology.

The immune system is divided into innate immunity and adaptive immunity.

In C. elegans, only innate immune response is seen. This includes antibiotic molecules, such as lectins, lysozyme and other antibacterial molecules. Caenorhabditis elegans can be used as a model organism to study the innate immune response to pathogens.

In general, C. elegans makes a great model organism candidate for their low cost and short reproductive time. The wide applications of C. elegans will bring greater enlightenment to the study of neurobiology, tumorigenesis, aging. the screening of natural compounds for human diseases.

Scientists at Creative Biolabs are dedicated to bringing together years of valuable experience to help our clients shorten the research journey. We are committed to the C. elegans antibody products and services, and dedicated to reducing the overall project development timeline for our clients.

Our provided hot target antibody products include the followings, but not limited to:

Reference

1. Hsiu V, Liao C. Use of Caenorhabditis elegans to study the potential bioactivity of natural compounds. J. Agric. Food Chem. 2018.