Researchers now have the tools to understand many of the world’s rarest diseases at a molecular level. Supported by in-house scientists and first-class technical platform, Creative Biolabs provides a full range of high-quality rare disease-related antibody products and services to facilitate your projects.
Rare disease defined differently in different regions. Although rare diseases may manifest in different ways, most of them appear inheritance - the Mendelian inheritance. Research shows that about 72% of rare diseases have genetic basis. A range of issues causes the remainder, such as bacterial infections, viruses, allergies and the environment where a person lives. Drugs are developing all the time which can help provide relief, offer a cure, or form the basis of a treatment protocol that allows the afflicted to manage their conditions better.
Antibody therapy is one of them. The major advantage of antibody therapy of rare disease is its highly specific. It can reduce the risk of toxicity because antibody therapy is targeted. This is particularly important in rare disease therapy and research because long-term treatment is frequently needed. In fact, symptom management is the best possible outcome for rare disease, which means taking a drug or treatment for a very long time.
Research Area of Rare Disease in Different Species
- Drosophila melanogaster (D. melanogaster)
As model organism, D. melanogaster is extremely valuable to the study of human rare diseases:
- It is straightforward to produce the corresponding genetic variant in flies with CRISPR-Cas9 technology and determine whether a phenotype related to the human disease is produced.
- D. melanogaster provides the most efficient system for genome-wide genetic screens for modifier loci, which credits to comprehensive collections of publicly-available fly lines.
Mouse model provides key information on rare disease mechanisms and therapeutic strategies:
- Mouse model becomes a promising tool to design evidence-based therapies to halt the progression of the rare aminoacidurias caused by defects in amino acid transporters, such as Slc16a10–/– Slc7a8–/– mouse.
- The model that delivering genes encoding mutated proteins into wild-type mice using adeno-associated viruses, has been developed to study arrhythmogenic right ventricular cardiomyopathy.
- A model for human oculocutaneous albinism 1, Tyr mutant mouse, has been employed to characterize vision and hearing deficits.
As the significant species with respect to the modelling of rare genetic human disease, sheep are:
- Relatively outbred and much more similar to human compared with mice in genetic and physiological composition.
- Domestic animals, thus, make it cost-effective large animal models, with highly efficient agriculture systems already established. Besides, they are easy maintenance and acceptance of human handling, which saves both time and money.
- Except for cloning, sheep model for inherited diseases can be established from naturally occurring variants.
- Sheep model has been employed for many rare diseases, such as Batten disease, GM2 gangliosidosis, Gaucher disease, Meckel-gruber syndrome.
As a reliable provider in the antibody products, scientists at Creative Biolabs are committed to develop rare disease-related products and services to meet various requirement for our clients. For further details, please feel free to contact us.
Our provided featured target antibody products include the followings, but not limited to:
|Cat#||Product Name||Host species||Species Reactivity||Application||Size||Conjugate||Alternative Names||Protein|
|CBMOAB-04865HCB||Mouse Anti-C. elegans HDA6 Antibody (CBMOAB-04865HCB)||Mouse||C. elegans (Caenorhabditis elegans)||WB, ELISA||0.5mg, 1mg, 200µg||Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP||Protein HDA-6, isoform c, hda-6||Submitted name: UBP-type domain-containing protein|
|CBMOAB-04866HCB||Mouse Anti-C. elegans HDA6 Antibody (CBMOAB-04866HCB)||Mouse||C. elegans (Caenorhabditis elegans)||WB, ELISA||0.5mg, 1mg, 200µg||Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP||Protein HDA-6, isoform d, hda-6||Submitted name: UBP-type domain-containing protein|
|CBMOAB-04867HCB||Mouse Anti-C. elegans HDA6 Antibody (CBMOAB-04867HCB)||Mouse||C. elegans (Caenorhabditis elegans)||WB, ELISA||0.5mg, 1mg, 200µg||Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP||Histone deacetylase 6, EC 126.96.36.199, hda-6||Histone deacetylase 6|
|MOFAB-020W||Rabbit Anti-RBP Antibody (MOFAB-020W)||Rabbit||Human, Mouse, Rat, Zebrafish||ELISA, WB, IP||100µL||None||CG31302, isoform G, Rbp, RBP||CG31302, isoform G|
|MOFAB-066W||Mouse Anti-Digoxin Antibody (MOFAB-066W)||Mouse||ELISA||0.5mg, 100µg||None||Digoxin, Digoxin||Digoxin|
|MOFY-0522-FY15||Mouse Anti-CD28 Antibody (MOFY-0522-FY15)||Mouse||Chicken, Turkey||FC, IHC||0.5mg||Biotin, FITC, NONE, PE||CD28 Molecule, CD28 Antigen, Tp44, T-Cell-Specific Surface Glycoprotein CD28, T-Cell-Specific Surface Glycoprotein, CD28 Antigen (Tp44)||CD28 Molecule|
|MOFY-0522-FY94||Rabbit Anti-GFAP (K39) Antibody (MOFY-0522-FY94)||Rabbit||Human, Mouse, Rat, Zebrafish||IHC, IHC-Fr, IHC-P, WB||100µL||NONE||Glial Fibrillary Acidic Protein, Intermediate Filament Protein, ALXDRD||Glial Fibrillary Acidic Protein|
|MOFY-0522-FY213||Mouse Anti-CAV-1 Antibody (MOFY-0522-FY213)||Mouse||Canine||Neut||100µg||NONE||Caveolin-1, cav-1||Caveolin-1|
|MOFY-0522-FY214||Mouse Anti-CAV-2 Antibody (MOFY-0522-FY214)||Mouse||Canine||Neut||100µg||NONE||CAV-2, Canine Adenovirus Type 2 (CAV-2)||Canine Adenovirus Type 2 (CAV-2)|
|MOFY-0522-FY215||Mouse Anti-CDV Antibody (MOFY-0522-FY215)||Mouse||Canine||IF, IHC, WB, ELISA||100µg||NONE||CDV, Canine Distemper Virus (CDV)||Canine Distemper Virus (CDV)|
|MOFY-0522-FY166||Chicken Anti-Canine Heartworm Antibody (MOFY-0522-FY166)||Chicken||Canine heartworm||ELISA, WB||100µg||NONE||Canine Heartworm|
|MOFY-0522-FY216||Mouse Anti-CDV Antibody (MOFY-0522-FY216)||Mouse||Canine||Neut||100µg||NONE||CDV, Canine Distemper Virus (CDV)||Canine Distemper Virus (CDV)|
|MOFY-0522-FY217||Pig Anti-CPI-2 Antibody (MOFY-0522-FY217)||Pig||Canine||IF||2mL||NONE||Cystatin C, Protein CPI-2, isoform a, cpi-2||Cystatin C|
|MOFY-0522-FY218||Mouse Anti-CPI-2 Antibody (MOFY-0522-FY218)||Mouse||Canine||IF, ELISA||100µg||NONE||Cystatin C, Protein CPI-2, isoform a, cpi-2||Cystatin C|
|MOFY-0522-FY219||Mouse Anti-CPV Antibody (MOFY-0522-FY219)||Mouse||Canine||IF, Neut||100µg||NONE||CPV, Canine Parvovirus (CPV)||Canine Parvovirus (CPV)|
|MOFY-0522-FY220||Mouse Anti-CAEV-63 Antibody (MOFY-0522-FY220)||Mouse||Caprine, Ovine||IF, IP||100µg||NONE||CAEV-63, Caprine Arthritis Encephalitis Virus||Caprine Arthritis Encephalitis Virus|
|MOFY-0522-FY221||Mouse Anti-CAEV-63 / CAEV-Co Antibody (MOFY-0522-FY221)||Mouse||Caprine, Ovine||IF, IP||100µg||NONE||CAEV-63 / CAEV-Co, Caprine Arthritis Encephalitis Virus (CAEV) MAb CAEV-63, CAEV-Co||Caprine Arthritis Encephalitis Virus (CAEV) MAb CAEV-63, CAEV-Co|
|MOFY-0522-FY222||Mouse Anti-CAEV-63 / CAEV-Co Antibody (MOFY-0522-FY222)||Mouse||Caprine, Ovine||IF, IP||100µg||NONE||CAEV-63 / CAEV-Co, Caprine Arthritis Encephalitis Virus (CAEV) MAb CAEV-63, CAEV-Co||Caprine Arthritis Encephalitis Virus (CAEV) MAb CAEV-63, CAEV-Co|
|MOFY-0522-FY223||Mouse Anti-CAEV-63 / CAEV-Co Antibody (MOFY-0522-FY223)||Mouse||Caprine, Ovine||IF, IP||100µg||NONE||CAEV-63 / CAEV-Co, Equine Arteritis Virus (EAV)||Equine Arteritis Virus (EAV)|
|MOFY-0522-FY224||Mouse Anti-EAV Antibody (MOFY-0522-FY224)||Mouse||Equine||IF, WB||100µg||NONE||EAV, Equine Arteritis Virus (EAV)||Equine Arteritis Virus (EAV)|
|MOFY-0522-FY225||Caprine Anti-EHV-1 Antibody (MOFY-0522-FY225)||Caprine||Equine||IF||2mL||NONE||EHV-1, Equine Herpesvirus Type 1 (EHV-1/ERV)||Equine Herpesvirus Type 1 (EHV-1/ERV)|
|MOFY-0522-FY226||Mouse Anti-Neospora caninum gp65 Antibody (MOFY-0522-FY226)||Mouse||Bovine, Canine, Neospora caninum||IF, ELISA, IHC, WB, DB||100µg||NONE||Neospora caninum gp65||Neospora caninum gp65|
|MOFY-0522-FY227||Mouse Anti-PI-3 p69 Antibody (MOFY-0522-FY227)||Mouse||Bovine||Neut, HA, IF||100µg||NONE||Parainfluenza Virus Type 3 (PI-3) MAb p69, PI-3 p69||Parainfluenza Virus Type 3 (PI-3) MAb p69|
|MOFY-0522-FY228||Caprine Anti-PI-3 p69 Antibody (MOFY-0522-FY228)||Caprine||Bovine||IF||2mL||NONE||Parainfluenza Virus Type 3 (PI-3) MAb p69, PI-3 p69||Parainfluenza Virus Type 3 (PI-3) MAb p69|
|MOFY-0522-FY230||Mouse Anti-PPV Antibody (MOFY-0522-FY230)||Mouse||Pig||IF, HA, RIA, IHC||100µg||NONE||Serine/threonine-protein phosphatase, EC 188.8.131.52, PpV||Serine/threonine-protein phosphatase|
|MOFY-0522-FY231||Mouse Anti-PRRSV Antibody (MOFY-0522-FY231)||Mouse||Bovine, Canine, Ovine, Cervine||IF, IP||100µg||NONE||PRRSV, Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)||Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)|
|MOFY-0522-FY232||Mouse Anti-PrP IHFG Antibody (MOFY-0522-FY232)||Mouse||Bovine, Ovine, Cervine||ELISA, IHC, WB||100µg||NONE||Prion Protein IHFG, PrP IHFG||Prion Protein IHFG|
|MOFY-0522-FY233||Mouse Anti-PRV gIII Antibody (MOFY-0522-FY233)||Mouse||Bovine, Canine, Ovine, Cervine, Feline, Mouse, Pig, Equine, Caprine, Camelid||IF, IP||100µg||NONE||PRV gIII, Pseudorabies Virus (PRV) MAb gIII||Pseudorabies Virus (PRV) MAb gIII|
|MOFY-0722-FY208||Rabbit Anti-UMOD Antibody (MOFY-0722-FY208)||Rabbit||Dog, Human, Mouse||WB, IHC, ICC, IP||100µL||None||Uromodulin, Tamm-Horsfall Urinary Glycoprotein, Uromucoid, THP, Uromodulin (Uromucoid, Tamm-Horsfall Glycoprotein), Tamm-Horsfall Glycoprotein, ADMCKD2||Uromodulin|