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Creative Biolabs is excited to greet you at the upcoming international conferences. Meet our team at the 13th Annual World ADC San Diego and the 13th Annual World Multispecific Summit in September, the 10th Annual Immuno-Oncology Summit in October, and the Antibody Engineering & Therapeutics (US) 2022 in December for expert consultation on your drug discovery projects. Shoot an email to arrange an in-person meeting!

Rare Disease

Researchers now have the tools to understand many of the world’s rarest diseases at a molecular level. Supported by in-house scientists and first-class technical platform, Creative Biolabs provides a full range of high-quality rare disease-related antibody products and services to facilitate your projects.

Background

Rare disease defined differently in different regions. Although rare diseases may manifest in different ways, most of them appear inheritance - the Mendelian inheritance. Research shows that about 72% of rare diseases have genetic basis. A range of issues causes the remainder, such as bacterial infections, viruses, allergies and the environment where a person lives. Drugs are developing all the time which can help provide relief, offer a cure, or form the basis of a treatment protocol that allows the afflicted to manage their conditions better.

Antibody therapy is one of them. The major advantage of antibody therapy of rare disease is its highly specific. It can reduce the risk of toxicity because antibody therapy is targeted. This is particularly important in rare disease therapy and research because long-term treatment is frequently needed. In fact, symptom management is the best possible outcome for rare disease, which means taking a drug or treatment for a very long time.

Research Area of Rare Disease in Different Species

  • Drosophila melanogaster (D. melanogaster)
Fig.1 Drosophila melanogaster (Wikipedia)

As model organism, D. melanogaster is extremely valuable to the study of human rare diseases:

    • It is straightforward to produce the corresponding genetic variant in flies with CRISPR-Cas9 technology and determine whether a phenotype related to the human disease is produced.
    • D. melanogaster provides the most efficient system for genome-wide genetic screens for modifier loci, which credits to comprehensive collections of publicly-available fly lines.
  • Mouse

Mouse model provides key information on rare disease mechanisms and therapeutic strategies:

Fig.2 Mouse (Wikipedia)
    • Mouse model becomes a promising tool to design evidence-based therapies to halt the progression of the rare aminoacidurias caused by defects in amino acid transporters, such as Slc16a10–/– Slc7a8–/– mouse.
    • The model that delivering genes encoding mutated proteins into wild-type mice using adeno-associated viruses, has been developed to study arrhythmogenic right ventricular cardiomyopathy.
    • A model for human oculocutaneous albinism 1, Tyr mutant mouse, has been employed to characterize vision and hearing deficits.
  • Sheep

As the significant species with respect to the modelling of rare genetic human disease, sheep are:

Fig.2 Sheep (Wikipedia)
    • Relatively outbred and much more similar to human compared with mice in genetic and physiological composition.
    • Domestic animals, thus, make it cost-effective large animal models, with highly efficient agriculture systems already established. Besides, they are easy maintenance and acceptance of human handling, which saves both time and money.
    • Except for cloning, sheep model for inherited diseases can be established from naturally occurring variants.
    • Sheep model has been employed for many rare diseases, such as Batten disease, GM2 gangliosidosis, Gaucher disease, Meckel-gruber syndrome.

As a reliable provider in the antibody products, scientists at Creative Biolabs are committed to develop rare disease-related products and services to meet various requirement for our clients. For further details, please feel free to contact us.

Our provided featured target antibody products include the followings, but not limited to:

Cat# Product Name Host species Species Reactivity Application Size Conjugate Alternative Names Protein
CBMOAB-04865HCB Mouse Anti-C. elegans HDA6 Antibody (CBMOAB-04865HCB) Mouse C. elegans (Caenorhabditis elegans) WB, ELISA 0.5mg, 1mg, 200µg Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP Protein HDA-6, isoform c, hda-6 Submitted name: UBP-type domain-containing protein
CBMOAB-04866HCB Mouse Anti-C. elegans HDA6 Antibody (CBMOAB-04866HCB) Mouse C. elegans (Caenorhabditis elegans) WB, ELISA 0.5mg, 1mg, 200µg Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP Protein HDA-6, isoform d, hda-6 Submitted name: UBP-type domain-containing protein
CBMOAB-04867HCB Mouse Anti-C. elegans HDA6 Antibody (CBMOAB-04867HCB) Mouse C. elegans (Caenorhabditis elegans) WB, ELISA 0.5mg, 1mg, 200µg Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP Histone deacetylase 6, EC 3.5.1.98, hda-6 Histone deacetylase 6
MOFAB-020W Rabbit Anti-RBP Antibody (MOFAB-020W) Rabbit Human, Mouse, Rat, Zebrafish ELISA, WB, IP 100µL None CG31302, isoform G, Rbp, RBP CG31302, isoform G
MOFAB-066W Mouse Anti-Digoxin Antibody (MOFAB-066W) Mouse ELISA 0.5mg, 100µg None Digoxin, Digoxin Digoxin
MOFY-0522-FY15 Mouse Anti-CD28 Antibody (MOFY-0522-FY15) Mouse Chicken, Turkey FC, IHC 0.5mg Biotin, FITC, NONE, PE CD28 Molecule, CD28 Antigen, Tp44, T-Cell-Specific Surface Glycoprotein CD28, T-Cell-Specific Surface Glycoprotein, CD28 Antigen (Tp44) CD28 Molecule
MOFY-0522-FY94 Rabbit Anti-GFAP (K39) Antibody (MOFY-0522-FY94) Rabbit Human, Mouse, Rat, Zebrafish IHC, IHC-Fr, IHC-P, WB 100µL NONE Glial Fibrillary Acidic Protein, Intermediate Filament Protein, ALXDRD Glial Fibrillary Acidic Protein
MOFY-0522-FY213 Mouse Anti-CAV-1 Antibody (MOFY-0522-FY213) Mouse Canine Neut 100µg NONE Caveolin-1, cav-1 Caveolin-1
MOFY-0522-FY214 Mouse Anti-CAV-2 Antibody (MOFY-0522-FY214) Mouse Canine Neut 100µg NONE CAV-2, Canine Adenovirus Type 2 (CAV-2) Canine Adenovirus Type 2 (CAV-2)
MOFY-0522-FY215 Mouse Anti-CDV Antibody (MOFY-0522-FY215) Mouse Canine IF, IHC, WB, ELISA 100µg NONE CDV, Canine Distemper Virus (CDV) Canine Distemper Virus (CDV)
MOFY-0522-FY166 Chicken Anti-Canine Heartworm Antibody (MOFY-0522-FY166) Chicken Canine heartworm ELISA, WB 100µg NONE Canine Heartworm
MOFY-0522-FY216 Mouse Anti-CDV Antibody (MOFY-0522-FY216) Mouse Canine Neut 100µg NONE CDV, Canine Distemper Virus (CDV) Canine Distemper Virus (CDV)
MOFY-0522-FY217 Pig Anti-CPI-2 Antibody (MOFY-0522-FY217) Pig Canine IF 2mL NONE Cystatin C, Protein CPI-2, isoform a, cpi-2 Cystatin C
MOFY-0522-FY218 Mouse Anti-CPI-2 Antibody (MOFY-0522-FY218) Mouse Canine IF, ELISA 100µg NONE Cystatin C, Protein CPI-2, isoform a, cpi-2 Cystatin C
MOFY-0522-FY219 Mouse Anti-CPV Antibody (MOFY-0522-FY219) Mouse Canine IF, Neut 100µg NONE CPV, Canine Parvovirus (CPV) Canine Parvovirus (CPV)
MOFY-0522-FY220 Mouse Anti-CAEV-63 Antibody (MOFY-0522-FY220) Mouse Caprine, Ovine IF, IP 100µg NONE CAEV-63, Caprine Arthritis Encephalitis Virus Caprine Arthritis Encephalitis Virus
MOFY-0522-FY221 Mouse Anti-CAEV-63 / CAEV-Co Antibody (MOFY-0522-FY221) Mouse Caprine, Ovine IF, IP 100µg NONE CAEV-63 / CAEV-Co, Caprine Arthritis Encephalitis Virus (CAEV) MAb CAEV-63, CAEV-Co Caprine Arthritis Encephalitis Virus (CAEV) MAb CAEV-63, CAEV-Co
MOFY-0522-FY222 Mouse Anti-CAEV-63 / CAEV-Co Antibody (MOFY-0522-FY222) Mouse Caprine, Ovine IF, IP 100µg NONE CAEV-63 / CAEV-Co, Caprine Arthritis Encephalitis Virus (CAEV) MAb CAEV-63, CAEV-Co Caprine Arthritis Encephalitis Virus (CAEV) MAb CAEV-63, CAEV-Co
MOFY-0522-FY223 Mouse Anti-CAEV-63 / CAEV-Co Antibody (MOFY-0522-FY223) Mouse Caprine, Ovine IF, IP 100µg NONE CAEV-63 / CAEV-Co, Equine Arteritis Virus (EAV) Equine Arteritis Virus (EAV)
MOFY-0522-FY224 Mouse Anti-EAV Antibody (MOFY-0522-FY224) Mouse Equine IF, WB 100µg NONE EAV, Equine Arteritis Virus (EAV) Equine Arteritis Virus (EAV)
MOFY-0522-FY225 Caprine Anti-EHV-1 Antibody (MOFY-0522-FY225) Caprine Equine IF 2mL NONE EHV-1, Equine Herpesvirus Type 1 (EHV-1/ERV) Equine Herpesvirus Type 1 (EHV-1/ERV)
MOFY-0522-FY226 Mouse Anti-Neospora caninum gp65 Antibody (MOFY-0522-FY226) Mouse Bovine, Canine, Neospora caninum IF, ELISA, IHC, WB, DB 100µg NONE Neospora caninum gp65 Neospora caninum gp65
MOFY-0522-FY227 Mouse Anti-PI-3 p69 Antibody (MOFY-0522-FY227) Mouse Bovine Neut, HA, IF 100µg NONE Parainfluenza Virus Type 3 (PI-3) MAb p69, PI-3 p69 Parainfluenza Virus Type 3 (PI-3) MAb p69
MOFY-0522-FY228 Caprine Anti-PI-3 p69 Antibody (MOFY-0522-FY228) Caprine Bovine IF 2mL NONE Parainfluenza Virus Type 3 (PI-3) MAb p69, PI-3 p69 Parainfluenza Virus Type 3 (PI-3) MAb p69
MOFY-0522-FY230 Mouse Anti-PPV Antibody (MOFY-0522-FY230) Mouse Pig IF, HA, RIA, IHC 100µg NONE Serine/threonine-protein phosphatase, EC 3.1.3.16, PpV Serine/threonine-protein phosphatase
MOFY-0522-FY231 Mouse Anti-PRRSV Antibody (MOFY-0522-FY231) Mouse Bovine, Canine, Ovine, Cervine IF, IP 100µg NONE PRRSV, Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)
MOFY-0522-FY232 Mouse Anti-PrP IHFG Antibody (MOFY-0522-FY232) Mouse Bovine, Ovine, Cervine ELISA, IHC, WB 100µg NONE Prion Protein IHFG, PrP IHFG Prion Protein IHFG
MOFY-0522-FY233 Mouse Anti-PRV gIII Antibody (MOFY-0522-FY233) Mouse Bovine, Canine, Ovine, Cervine, Feline, Mouse, Pig, Equine, Caprine, Camelid IF, IP 100µg NONE PRV gIII, Pseudorabies Virus (PRV) MAb gIII Pseudorabies Virus (PRV) MAb gIII
MOFY-0722-FY208 Rabbit Anti-UMOD Antibody (MOFY-0722-FY208) Rabbit Dog, Human, Mouse WB, IHC, ICC, IP 100µL None Uromodulin, Tamm-Horsfall Urinary Glycoprotein, Uromucoid, THP, Uromodulin (Uromucoid, Tamm-Horsfall Glycoprotein), Tamm-Horsfall Glycoprotein, ADMCKD2 Uromodulin
For Research Use Only | Not For Clinical Use.