Connect with Us at the Upcoming Events

With in-person events back again, Creative Biolabs is excited to greet you at the upcoming international conferences. Meet our team at 2022 BIO International Convention in June (booth #1754) and at the 13th Annual World ADC San Diego in September (booth number to be updated) for expert consultation on your drug discovery. Shoot an email to arrange an in-person meeting!

Rare Disease

Researchers now have the tools to understand many of the world’s rarest diseases at a molecular level. Supported by in-house scientists and first-class technical platform, Creative Biolabs provides a full range of high-quality rare disease-related antibody products and services to facilitate your projects.

Background

Rare disease defined differently in different regions. Although rare diseases may manifest in different ways, most of them appear inheritance - the Mendelian inheritance. Research shows that about 72% of rare diseases have genetic basis. A range of issues causes the remainder, such as bacterial infections, viruses, allergies and the environment where a person lives. Drugs are developing all the time which can help provide relief, offer a cure, or form the basis of a treatment protocol that allows the afflicted to manage their conditions better.

Antibody therapy is one of them. The major advantage of antibody therapy of rare disease is its highly specific. It can reduce the risk of toxicity because antibody therapy is targeted. This is particularly important in rare disease therapy and research because long-term treatment is frequently needed. In fact, symptom management is the best possible outcome for rare disease, which means taking a drug or treatment for a very long time.

Research Area of Rare Disease in Different Species

  • Drosophila melanogaster (D. melanogaster)
Fig.1 Drosophila melanogaster (Wikipedia)

As model organism, D. melanogaster is extremely valuable to the study of human rare diseases:

    • It is straightforward to produce the corresponding genetic variant in flies with CRISPR-Cas9 technology and determine whether a phenotype related to the human disease is produced.
    • D. melanogaster provides the most efficient system for genome-wide genetic screens for modifier loci, which credits to comprehensive collections of publicly-available fly lines.
  • Mouse

Mouse model provides key information on rare disease mechanisms and therapeutic strategies:

Fig.2 Mouse (Wikipedia)
    • Mouse model becomes a promising tool to design evidence-based therapies to halt the progression of the rare aminoacidurias caused by defects in amino acid transporters, such as Slc16a10–/– Slc7a8–/– mouse.
    • The model that delivering genes encoding mutated proteins into wild-type mice using adeno-associated viruses, has been developed to study arrhythmogenic right ventricular cardiomyopathy.
    • A model for human oculocutaneous albinism 1, Tyr mutant mouse, has been employed to characterize vision and hearing deficits.
  • Sheep

As the significant species with respect to the modelling of rare genetic human disease, sheep are:

Fig.2 Sheep (Wikipedia)
    • Relatively outbred and much more similar to human compared with mice in genetic and physiological composition.
    • Domestic animals, thus, make it cost-effective large animal models, with highly efficient agriculture systems already established. Besides, they are easy maintenance and acceptance of human handling, which saves both time and money.
    • Except for cloning, sheep model for inherited diseases can be established from naturally occurring variants.
    • Sheep model has been employed for many rare diseases, such as Batten disease, GM2 gangliosidosis, Gaucher disease, Meckel-gruber syndrome.

As a reliable provider in the antibody products, scientists at Creative Biolabs are committed to develop rare disease-related products and services to meet various requirement for our clients. For further details, please feel free to contact us.

Our provided featured target antibody products include the followings, but not limited to:

Cat# Product Name Host species Species Reactivity Application Size Conjugate Alternative Names Protein
CBMOAB-04865HCB Mouse Anti-C. elegans HDA6 Antibody (CBMOAB-04865HCB) Mouse C. elegans (Caenorhabditis elegans) WB, ELISA 0.5mg, 1mg, 200µg Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP Protein HDA-6, isoform c, hda-6 Submitted name: UBP-type domain-containing protein
CBMOAB-04866HCB Mouse Anti-C. elegans HDA6 Antibody (CBMOAB-04866HCB) Mouse C. elegans (Caenorhabditis elegans) WB, ELISA 0.5mg, 1mg, 200µg Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP Protein HDA-6, isoform d, hda-6 Submitted name: UBP-type domain-containing protein
CBMOAB-04867HCB Mouse Anti-C. elegans HDA6 Antibody (CBMOAB-04867HCB) Mouse C. elegans (Caenorhabditis elegans) WB, ELISA 0.5mg, 1mg, 200µg Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP Histone deacetylase 6, EC 3.5.1.98, hda-6 Histone deacetylase 6
MOFAB-020W Rabbit Anti-RBP Antibody (MOFAB-020W) Rabbit Human, Mouse, Rat, Zebrafish ELISA, WB, IP 100µL None CG31302, isoform G, Rbp, RBP CG31302, isoform G
MOFAB-066W Mouse Anti-Digoxin Antibody (MOFAB-066W) Mouse ELISA 0.5mg, 100µg None Digoxin, Digoxin Digoxin
For Research Use Only | Not For Clinical Use.