Cellular Marker

Supported by in-house scientists and first-class technical platform, Creative Biolabs provides a full range of high-quality cellular marker antibody products and services to facilitate your project success.

Background

Cellular markers are special proteins and carbohydrates attached to the cell membrane. Compared to some proteins that have the function of allowing the transport of molecules across the membrane, cellular markers play a primary role in intercellular communication and recognition. Cellular markers can be used to identify specific cells and monitor cell growth and differentiation. It is also used in the diagnosis and treatment of many diseases.

Fig. 1 Cell surface markers expressed by mouse and human long-lived plasma cells. (Brynjolfsson, 2018)

Research Area of Cellular Marker in Different Species

• Zebrafish

Previously, zebrafish is not defined as the ideal culture conditions for embryonic stem (ES) cells because the knowledge of pluripotency markers in zebrafish is almost nonexistent. Recently study has shown that stage-specific embryonic antigen 1 (SSEA1) is a marker that precedes the expression of pluripotency genes in a zebrafish embryonic cell colony, in the same way that SOX2 precedes nestin expression in those colonies that have already started differentiation toward neurons, which means a step forward in the knowledge of zebrafish pluripotency markers.

• Rhesus

CD28, CD80, and CD86 are co-stimulatory molecules that are necessary for the proper stimulation of T-cells. Researches have demonstrated that rhesus monkey peripheral B-cells expressed the ligands for CD28, CD80, and CD86. CD80 could be found on about two-thirds of B-cells, the proportion of CD86 expressing cells being slightly lower. The expression level of CD20 on CD80⁺ B-cells was higher than the one on CD21⁺ B-cells indicating that these antigens were expressed on different subsets of rhesus monkey peripheral blood B-cells.

• Arabidopsis

The preprophase band (PPB), a cortical ring of microtubules and F-actin, disassembles upon nuclear-envelope breakdown. RanGAP is the GTPase activating protein of the small GTPase Ran, which provides spatial information for nucleocytoplasmic transport and various mitotic processes in animals. Researches have shown that Arabidopsis RanGAP, a continuous positive protein marker of the plant division plane, has a role in spatial signaling during plant cell division.

Reference

1. Brynjolfsson, S.F.; et al. Long-Lived Plasma Cells in Mice and Men. Front Immunol. 2018, 9: 2673.

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