Connect with Us at the Upcoming Events

With in-person events back again, Creative Biolabs is excited to greet you at the upcoming international conferences. Meet our team at 2022 BIO International Convention in June (booth #1754) and at the 13th Annual World ADC San Diego in September (booth number to be updated) for expert consultation on your drug discovery. Shoot an email to arrange an in-person meeting!

Genetic Disease

Supported by in-house scientists and first-class technical platform, Creative Biolabs provides a full range of high-quality genetic disease-related products and services to facilitate your project success.

Background

Mutation is a harmful change to a gene, also known as a pathogenic variant. Genetic disease occurs when a mutation affects your genes or when you have the wrong amount of genetic material. When you received half genes from each biological parent, you may inherit a gene mutation from one or both parents. Besides, genes can change due to issues within the DNA mutations, which can raise your risk of gaining a genetic disorder. Some symptoms generate at birth, while others develop over time.

Genetic diseases have many types, which include but not limited following categories:

Chromosomal disorders Down syndrome; FragileX syndrome; Klinefelter syndrome; Triple-X syndrome; Turner syndrome; Trisomy 18; Trisomy 13.
Multifactorial disorders Alzheimer's disease; Arthritis; Autism spectrum disorder; Coronary artery disease; Diabates; Migraine headaches; Spina bifida; Isolated congenital heart defects.
Monogenic disorders Cystic fibrosis; Congenital deafness; Duchenne muscular dystrophy; Familial hypercholesterolemia; Hemochromatosis; Neurofibromatosis type 1; Sickle cell disease; Tay-Sachs disease.

Fig.1 Diagram featuring examples of a disease located on each chromosome. (Wikipedia) Fig.1 Diagram featuring examples of a disease located on each chromosome. (Wikipedia)

Learning more about genes and DNA in your body is helpful to understand genetic disorder causes. Because most of the DNA in your genes instructs the body to make proteins, which start complex cell interactions that help you stay healthy. When a mutation occurs, it affects the genes' protein-making instructions, as well as missing proteins. Environmental factors that could lead to a genetic mutation include:

  • Chemical exposure
  • Radiation exposure
  • Smoking
  • UV exposure from the sun

Research Area of Genetic Disease in Different Species

  • Zebrafish

Zebrafish has many characteristics that make it becomes a valuable model for studying human genetics and diseases:

Fig.2 Zebrafish. (Wikipedia)
    • 84 percent of genes associated with human disease have a zebrafish counterpart.
    • As a vertebrate, zebrafish has the same major organs and tissues as humans.
    • The zebrafish genome has been fully sequenced to a very high quality.
    • The zebrafish genome has many gene duplications, resulting in gene subfunctionalization and neofunctionalization.
  • Mouse

Mouse is the pre-eminent model organism for the study of mammalian gene function and has provided an extraordinarily rich range of insights into basic genetic mechanisms and biological systems:

Fig.3 Mouse. (Wikipedia)
    • The characterization of mouse mutants has illuminated the relationship between gene and phenotype, providing transformational insights into the genetic bases of disease.
    • The mouse genetics is employing a range of diversity resources to delineate gene-gene and gene-environment interactions and to explore genetic context.
    • The mouse genetics is a powerful tool for assessing the functional impact of human genetic variation and determining the causal relationship between variant and disease.

As a reliable provider in the antibody products, scientists at Creative Biolabs are committed to develop genetic disease products and services to meet various requirement for our clients. For further details about genetic disease-related products, please feel free to contact us.

Our provided featured target antibody products include the followings, but not limited to:

Cat# Product Name Host species Species Reactivity Application Size Conjugate Alternative Names Protein
CBMOAB-00815HCB Mouse Anti-C. elegans ATX3 Antibody (CBMOAB-00815HCB) Mouse C. elegans (Caenorhabditis elegans) WB, ELISA 0.5mg, 1mg, 200µg Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP Ataxin-3 homolog, EC 3.4.19.12, Machado-Joseph disease-like protein, atx-3 Ataxin-3 homolog
CBMOAB-02495HCB Mouse Anti-C. elegans DAF2 Antibody (CBMOAB-02495HCB) Mouse C. elegans (Caenorhabditis elegans) WB, ELISA 0.5mg, 1mg, 200µg Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP Insulin-like receptor, IR, EC 2.7.10.1, Abnormal dauer formation protein 2, [Cleaved into: Insulin-like receptor subunit alpha, Insulin-like receptor subunit beta], daf-2 Insulin-like receptor
CBMOAB-02823HCB Mouse Anti-C. elegans DNJ27 Antibody (CBMOAB-02823HCB) Mouse C. elegans (Caenorhabditis elegans) WB, ELISA 0.5mg, 1mg, 200µg Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP Protein DNJ-27, isoform b, dnj-27 Submitted name: DnaJ homolog subfamily C member 10
CBMOAB-02824HCB Mouse Anti-C. elegans DNJ27 Antibody (CBMOAB-02824HCB) Mouse C. elegans (Caenorhabditis elegans) WB, ELISA 0.5mg, 1mg, 200µg Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP Protein DNJ-27, isoform a, dnj-27 DnaJ homolog subfamily C member 10
CBMOAB-13187HCB Mouse Anti-C. elegans VPS41 Antibody (CBMOAB-13187HCB) Mouse C. elegans (Caenorhabditis elegans) WB, ELISA 0.5mg, 1mg, 200µg Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP Vacuolar protein sorting-associated protein 41 homolog, vps-41 Vacuolar protein sorting-associated protein 41 homolog
MOFAB-504W Mouse Anti-Rainbow trout sdy Antibody (MOFAB-504W) Mouse Rainbow trout WB 100µL, 50µL NONE Sexually dimorphic on the Y chromosome, sdy Sexually dimorphic on the Y chromosome
MOFAB-505W Mouse Anti-Rainbow trout sdy Antibody (MOFAB-505W) Mouse Rainbow trout WB 100µL, 50µL NONE Sexually dimorphic on the Y chromosome, sdy Sexually dimorphic on the Y chromosome
MOFAB-786W Mouse Anti-CAT Antibody (MOFAB-786W) Mouse Chicken, Human, Mouse, Rat WB, IHC, IP 100µL, 50µL NONE Catalase, catalase 1, CTA1, HGNC:1516, MGC138422, MGC138424, 2210418N07, Cas-1, Cas1, CAT, Cat01, Catl, Cs-1, CS1 Catalase
For Research Use Only | Not For Clinical Use.