Genetic Disease

Supported by in-house scientists and first-class technical platform, Creative Biolabs provides a full range of high-quality genetic disease-related products and services to facilitate your project success.

Background

Mutation is a harmful change to a gene, also known as a pathogenic variant. Genetic disease occurs when a mutation affects your genes or when you have the wrong amount of genetic material. When you received half genes from each biological parent, you may inherit a gene mutation from one or both parents. Besides, genes can change due to issues within the DNA mutations, which can raise your risk of gaining a genetic disorder. Some symptoms generate at birth, while others develop over time.

Genetic diseases have many types, which include but not limited following categories：

Chromosomal disorders Down syndrome; FragileX syndrome; Klinefelter syndrome; Triple-X syndrome; Turner syndrome; Trisomy 18; Trisomy 13.
Multifactorial disorders Alzheimer's disease; Arthritis; Autism spectrum disorder; Coronary artery disease; Diabates; Migraine headaches; Spina bifida; Isolated congenital heart defects.
Monogenic disorders Cystic fibrosis; Congenital deafness; Duchenne muscular dystrophy; Familial hypercholesterolemia; Hemochromatosis; Neurofibromatosis type 1; Sickle cell disease; Tay-Sachs disease.

Fig.1 Diagram featuring examples of a disease located on each chromosome. (Wikipedia) Fig.1 Diagram featuring examples of a disease located on each chromosome. (Wikipedia)

Learning more about genes and DNA in your body is helpful to understand genetic disorder causes. Because most of the DNA in your genes instructs the body to make proteins, which start complex cell interactions that help you stay healthy. When a mutation occurs, it affects the genes' protein-making instructions, as well as missing proteins. Environmental factors that could lead to a genetic mutation include:

  • Chemical exposure
  • Radiation exposure
  • Smoking
  • UV exposure from the sun

Research Area of Genetic Disease in Different Species

Zebrafish

Zebrafish has many characteristics that make it becomes a valuable model for studying human genetics and diseases:

Fig.2 Zebrafish. (Wikipedia)
  • 84 percent of genes associated with human disease have a zebrafish counterpart.
  • As a vertebrate, zebrafish has the same major organs and tissues as humans.
  • The zebrafish genome has been fully sequenced to a very high quality.
  • The zebrafish genome has many gene duplications, resulting in gene subfunctionalization and neofunctionalization.
Mouse

Mouse is the pre-eminent model organism for the study of mammalian gene function and has provided an extraordinarily rich range of insights into basic genetic mechanisms and biological systems:

Fig.3 Mouse. (Wikipedia)
  • The characterization of mouse mutants has illuminated the relationship between gene and phenotype, providing transformational insights into the genetic bases of disease.
  • The mouse genetics is employing a range of diversity resources to delineate gene-gene and gene-environment interactions and to explore genetic context.
  • The mouse genetics is a powerful tool for assessing the functional impact of human genetic variation and determining the causal relationship between variant and disease.

As a reliable provider in the antibody products, scientists at Creative Biolabs are committed to develop genetic disease products and services to meet various requirement for our clients. For further details about genetic disease-related products, please feel free to contact us.

Our provided featured target antibody products include the followings, but not limited to:

  • Mouse Anti-ATX3 Antibody (CBMOAB-00815HCB) (CAT#: CBMOAB-00815HCB)

    • Host species: Mouse
    • Species Reactivity: C. elegans (Caenorhabditis elegans), A. thaliana (Arabidopsis thaliana)
    • Application: WB, ELISA
    • Protein: Ataxin-3 homolog
    • Size: 0.5mg, 1mg, 200µg
    • Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
    • Alternative Names: Ataxin-3 homolog, EC 3.4.19.12, Machado-Joseph disease-like protein, atx-3

  • Mouse Anti-C. elegans DAF2 Antibody (CBMOAB-02495HCB) (CAT#: CBMOAB-02495HCB)

    • Product Overview: Mouse Anti-C. elegans DAF2 Antibody is a mouse antibody against DAF2. It can be used for DAF2 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
    • Host species: Mouse
    • Species Reactivity: C. elegans (Caenorhabditis elegans)
    • Application: WB, ELISA
    • Protein: Insulin-like receptor
    • Size:
    • Conjugate:
    • Alternative Names: Insulin-like receptor, IR, EC 2.7.10.1, Abnormal dauer formation protein 2, [Cleaved into: Insulin-like receptor subunit alpha, Insulin-like receptor subunit beta], daf-2
    • COA

  • Mouse Anti-C. elegans DNJ27 Antibody (CBMOAB-02824HCB) (CAT#: CBMOAB-02824HCB)

    • Host species: Mouse
    • Species Reactivity: C. elegans (Caenorhabditis elegans)
    • Application: WB, ELISA
    • Protein: DnaJ homolog subfamily C member 10
    • Size: 0.5mg, 1mg, 200µg
    • Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
    • Alternative Names: Protein DNJ-27, isoform a, dnj-27

  • Mouse Anti-sdy Antibody (MOFAB-504W) (CAT#: MOFAB-504W)

    • Host species: Mouse
    • Species Reactivity: Rainbow trout, O. mykiss (Oncorhynchus mykiss)
    • Application: WB
    • Protein: Sexually dimorphic on the Y chromosome
    • Size: 100µL, 50µL
    • Conjugate: NONE
    • Alternative Names: Sexually dimorphic on the Y chromosome, sdy
Online Inquiry
For Research Use Only | Not For Clinical Use.
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number