Mouse Anti-D. melanogaster Fen1 Antibody (CBMOAB-16738FYA)
Cat: CBMOAB-16738FYA
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- Product Details
Specifications
Host species | Mouse (Mus musculus) |
Species Reactivity | Fruit fly (Drosophila melanogaster) |
Clone | MO16738FYA |
Specificity | This antibody binds to fruit fly Fen1. |
Format | Liquid or Lyophilized |
Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
Purity | > 90% was determined by SDS-PAGE |
Purification | Purified with Protein A or G affinity chromatography |
Cellular Localization | Nucleus; Mitochondrion |
Application Information
Application | WB, ELISA |
Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
Introduction | The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. |
Product Overview | Mouse Anti-D. melanogaster Fen1 Antibody is a mouse antibody against Fen1. It can be used for Fen1 detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
Alternative Names | Flap endonuclease 1; FEN-1; EC 3.1.-.-; Flap structure-specific endonuclease 1; Fen1 |
UniProt ID | Q7K7A9 |
Protein Refseq | The length of the protein is 385 amino acids long. The sequence is show below: MGILGLSKLIADLAPQAIRESEMKHFFGRKVAIDASMCLYQFLIAVRSEGAQLATVNGDPTSHLMGMFYRTIRLLDNGIKPVYVFDGKPPDLKSGELAKRAERREEAEKALKAATDAGDDAGIEKFNRRLVRVTKEHAKEAKELLTLMGVPYVDAPCEAEAQCAALVKAGKVYATATEDMDALTFGSTKLLRYLTYSEARKMPVKEFSYDKLLEGLAINNREFIDLCILLGCDYCESIKGIGPKRAIELINTYRDIETILDNLDSSKYTVPENWNYKVARELFIEPEVADADSIDLKWVEPDEEGLVKFLCGDRQFNEERVRNGAKKLMKSKQAQTQVRLDSFFKTLPSTPNATNAAKRKAEEAKKSANNKKAKTSGGGRGRRPK. |
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MO-AB-00479R | Mouse Anti-Medaka FEN1 Antibody (MO-AB-00479R) |
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For Research Use Only | Not For Clinical Use.
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