Histone deacetylase

HDA6 is responsible for the deacetylation of the N-terminal lysine residues of the core histones (H2A, H2B, H3, and H4). HDA6 may only remove acetyl residues from specific targets, such as rDNA repetitive sequences or complex transgenes. Histone deacetylation provides a label for epigenetic suppression and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Histone deacetylase works by forming large multiprotein complexes. HDA6 is required for rRNA gene silencing in nucleolar dominance. HDA6 plays a role in transgene silencing, but this effect does not seem to be related to histone deacetylase activity.