Mediator of RNA polymerase II transcription subunit 12
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome.
Mouse Anti-MED12 Antibody (CBMOAB-36335FYC) (CAT#: CBMOAB-36335FYC)
-
- Host species: Mouse
- Species Reactivity: A. thaliana (Arabidopsis thaliana), Chimpanzee (Pan troglodytes), Marmoset, Pig (Sus scrofa), Rhesus (Macaca mulatta), Zebrafish (Danio rerio)
- Application: WB, ELISA
- Protein: Mediator of RNA polymerase II transcription subunit 12
- Size: 0.5mg, 1mg, 200µg
- Conjugate: AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, None, PE, PerCP
- Alternative Names: Mediator Complex Subunit 12, Thyroid Hormone Receptor-Associated Protein Complex 230 KDa Component, Trinucleotide Repeat-Containing Gene 11 Protein, Activator-Recruited Cofactor 240 KDa Component, OPA-Containing Protein, CAG Repeat Protein 45, TRAP230, TNRC11, ARC240, CAGH45, HOPA, Mediator Of RNA Polymerase II Transcription, Subunit 12 Homolog (S. Cerevisiae), Trinucleotide Repeat Containing 11 (THR-Associated Protein, 230 KDa Subunit), Trinucleotide Repeat Containing 11 (THR-Associated Protein, 230kDa Subunit)
For Research Use Only | Not For Clinical Use.
