Mouse Anti-Arabidopsis BRCA1 Antibody (CBMOAB-25468FYC)


Cat: CBMOAB-25468FYC
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityA. thaliana (Arabidopsis thaliana)
CloneMO25468FC
SpecificityThis antibody binds to Arabidopsis BRCA1.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationNucleus; Plasma Membrane

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionThis gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
Product OverviewMouse Anti-Arabidopsis BRCA1 Antibody is a mouse antibody against BRCA1. It can be used for BRCA1 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesBRCA1, DNA Repair Associated; Protein Phosphatase 1, Regulatory Subunit 53; BRCA1/BRCA2-Containing Complex, Subunit 1; Fanconi Anemia, Complementation Group S; Breast Cancer 1, Early Onset; RING Finger Protein 53; RNF53; Breast And Ovarian Cancer Susceptibility Protein 1; Breast Cancer Type 1 Susceptibility Protein; RING-Type E3 Ubiquitin Transferase BRCA1; Early Onset Breast Cancer 1; Breast Cancer 1
UniProt IDQ8RXD4
Protein RefseqThe length of the protein is 941 amino acids long. The sequence is show below: MADTSHLERMGRELKCPICLSLYNSAVSLSCNHVFCNACIVKSMKMDATCPVCKIPYHRREIRGAPHMDSLVSIYKNMEDASGIKLFVSQNNPSPSDKEKQVRDASVEKASDKNRQGSRKGRASKRNEYGKTKEIDVDAPGPIVMKPSSQTKKRVQLLQNLSAESLTKPTESVETAEKPKDYTENTVIRLDEHPSLNKEGNLSPFFWLRDEDDGENSSQRTESDQLLGTTPVNVPSFSDLMDSDHESPSKEDEQQKPNPGDMFDSEMFEWTQRPCSPEILPSPVKAKVLGRDEIDLTQKKLPKVKVASSKCKNRKAGSARNTVARRSIGVSQEDNMESSAAATISEQQDSRGTSGTIIRNDVNTDENVKAKRATRSKAQSTRVQSDLNVSNEADGKQGTKRKRSSIKSSPAHPIAGPNELSLGTEIVGKGDQDQAHGPSDTHPEKRSPTEKPSLKKRGRKSNASSSLKDLSGKTQKKTSEKKLKLDSHMISSKATQPHGNGILTAGLNQGGDKQDSRNNRKSTVGKDDHTMQVIEKCSTINKSSSGGSAHLRRCNGSLTKKFTCAFCQCSEDTEASGEMTHYYRGEPVSADFNGGSKVIHVHKNCAEWAPNVYFNDLTIVNLDVELTRSRRISCSCCGLKGAALGCYNKSCKNSFHVTCAKLIPECRWDNVKFVMLCPLDASIKLPCEEANSKDRKCKRTPKEPLHSQPKQVSGKANIRELHIKQFHGFSKKLVLSCSGLTVEEKTVIAEFAELSGVTISKNWDSTVTHVIASINENGACKRTLKFMMAILEGKWILTIDWIKACMKNTKYVSEEPYEITMDVHGIREGPYLGRQRALKKKPKLFTGLKFYIMGDFELAYKGYLQDLIVAAGGTILRRRPVSSDDNEASTIVVFSVEPSKKKTLTQRRSDAEALAKSARARAASSSWVLDSIAGCQILVLI.
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For Research Use Only | Not For Clinical Use.
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