Mouse Anti-Arabidopsis RAD17 Antibody (CBMOAB-39745FYC)
Cat: CBMOAB-39745FYC
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- Product Details
Specifications
Host species | Mouse (Mus musculus) |
Species Reactivity | A. thaliana (Arabidopsis thaliana) |
Clone | MO39745FC |
Specificity | This antibody binds to Arabidopsis RAD17. |
Format | Liquid or Lyophilized |
Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
Purity | > 90% was determined by SDS-PAGE |
Purification | Purified with Protein A or G affinity chromatography |
Cellular Localization | Nucleus |
Application Information
Application | WB, ELISA |
Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
Introduction | The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. |
Product Overview | Mouse Anti-Arabidopsis RAD17 Antibody is a mouse antibody against RAD17. It can be used for RAD17 detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
Alternative Names | RAD17 Checkpoint Clamp Loader Component; HRAD17; R24L; Cell Cycle Checkpoint Protein (RAD17); Cell Cycle Checkpoint Protein RAD17; RAD17 Homolog (S. Pombe); RF-C Activator 1 Homolog; RF-C/Activator 1 Homolog |
UniProt ID | Q9MBA3 |
Protein Refseq | The length of the protein is 599 amino acids long. The sequence is show below: MLKKKLSLEDEDDDRSYNLRSSRSNAKSKPRSSAGTATNPRASKRARLSGASATQEDSSLVDKIRLSFEDFDEALSGFKVSSGYERSKNTDLWVDKYRPRTLEELSVHKKKVDEVKLWFQESLDFLKNGLRNNVLLVTGQAGVGKSATIHLITSILGVTVHEWNAPIPTIWQEHVHNTSSGLKYTSKLDEFENFVESTRKYGVMASSSTDGIKAPVVLLIDDLPLANGRHAFERLQNCLLLLVKSTQIPTVILITDHNNADSSDQTARRMEDTQSSLERAGALKVAFNPITKNSIKKVLQRICREEHCKVTTMEIDQMATASGGDIRHAITSLQLFSVKPELNHTKIKSPRPGMEDNYHGNEQTMYSGLDSGISSCFGRDETLSLFHALGKFLHNKRETDNVIISECSSSLVHDEFARLPLKMDAPEKVLSQAHGQAGRVVDFLHENVLDFVSDGAIEDAWCVSSYLADADLLLADIRGKMSGHNNTEDVPQSAGASVAVRGVLYGNKQPCSSRWHVIRKPKLWQVEQSSIQTKKNLREQRNISYEGSRVADISVMATEYSPVLKWLSYRASPDAFPGMGEETDEEDSDISEDDEIQDW. |
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For Research Use Only | Not For Clinical Use.
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